Brief Report: Relationship Between Non-verbal IQ and Gender in Autism

被引：0
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作者：
Ryan Banach
Ann Thompson
Peter Szatmari
Jeremy Goldberg
Lawrence Tuff
Lonnie Zwaigenbaum
William Mahoney
机构：
[1] McMaster University,Department of Family Medicine
[2] McMaster University,Department of Psychiatry and Behavioural Neurosciences
[3] University of Alberta,Department of Pediatrics
[4] McMaster University,Department of Pediatrics
[5] McMaster University,Offord Centre for Child Studies
来源：
Journal of Autism and Developmental Disorders | 2009年 / 39卷
关键词：
Autism; IQ; Gender; Genetic;
D O I：
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中图分类号：
学科分类号：
摘要：
It has been proposed that females at risk for autism are protected in some way, so that only those with the greatest genetic liability are affected. Consequently, affected male siblings of females with autism should be more impaired than affected male siblings of male probands. One hundred and ninety-four (194) families with a single child with autism (simplex, SPX) and 154 families with more than one child with autism (multiplex, MPX) were examined on measures of severity, including non-verbal IQ. Among SPX families, girls had lower IQ than boys, but no such differences were seen among MPX families. Similarly, the affected brothers of girls with autism were no different from affected brothers of male probands. These data suggest that MPX and SPX families differ with respect to the relationship between gender and IQ.
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