Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

被引：0
|
作者：
Jin Chen
Junqiu Chen
Yuanhang Cheng
Yunfeng Fu
Hongzhou Zhao
Minying Tang
Hu Zhao
Na Lin
Xiaohua Shi
Yan Lei
Shuiliang Wang
Lianghu Huang
Weizhen Wu
Jianming Tan
机构：
[1] Xiamen University,Fujian Provincial Key Laboratory of Transplant Biology, 900th Hospital
[2] Clinical Medical Institute of Fujian Medical University,Organ Transplant Institute, 900th Hospital
[3] Hubei University of Arts and Science,Xiangyang Central Hospital
来源：
Stem Cell Research & Therapy | / 11卷
关键词：
Mesenchymal stem cells; Exosomes; Hypoxia; Beta cells; ER stress;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Epidermal growth factor abrogates hypoxia-induced apoptosis in cultured human trophoblasts through phosphorylation of bad-serine-112 via the p38 MAPK pathway
    Nelson, D. M.
    Humphrey, R.
    Sonnenberg-Hirche, C.
    Smith, S.
    Hu, C.
    Barton, A.
    Sadovsky, Y.
    PLACENTA, 2007, 28 (8-9) : A76 - A76
  • [22] MiR-223-3p overexpressed adipose mesenchymal stem cell-derived exosomes promote wound healing via targeting MAPK10
    Liu, Xiaojiao
    Jin, Shunqiao
    Liu, Jiao
    Xu, Xuezhu
    ACTA HISTOCHEMICA, 2023, 125 (08)
  • [23] Exosomes Derived from Bone Mesenchymal Stem Cells Alleviate Compression-Induced Nucleus Pulposus Cell Apoptosis by Inhibiting Oxidative Stress
    Hu, Yiqiang
    Tao, Ranyang
    Wang, Linfang
    Chen, Lang
    Lin, Ze
    Panayi, Adriana C.
    Xue, Hang
    Li, Hui
    Xiong, Liming
    Liu, Guohui
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021
  • [24] Exosomes derived from miR-301a-3p-overexpressing adipose-derived mesenchymal stem cells reverse hypoxia-induced erectile dysfunction in rat models
    Liang, Li
    Zheng, Dachao
    Lu, Chao
    Xi, Qinghong
    Bao, Hua
    Li, Wengfeng
    Gu, Yufei
    Mao, Yuanshen
    Xu, Bin
    Gu, Xin
    STEM CELL RESEARCH & THERAPY, 2021, 12 (01)
  • [25] Exosomes derived from miR-301a-3p-overexpressing adipose-derived mesenchymal stem cells reverse hypoxia-induced erectile dysfunction in rat models
    Li Liang
    Dachao Zheng
    Chao Lu
    Qinghong Xi
    Hua Bao
    Wengfeng Li
    Yufei Gu
    Yuanshen Mao
    Bin Xu
    Xin Gu
    Stem Cell Research & Therapy, 12
  • [26] Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplat-ininduced ovarian granulosa cell stress and apoptosis in vitro
    Sun, Liping
    Li, Dong
    Song, Kun
    Wei, Jianlu
    Yao, Shu
    Li, Zhao
    Su, Xuantao
    Ju, Xiuli
    Chao, Lan
    Deng, Xiaohui
    Kong, Beihua
    Li, Li
    SCIENTIFIC REPORTS, 2017, 7
  • [27] Bone marrow-derived mesenchymal stem cells protect against cisplatin-induced acute kidney injury in rats by inhibiting cell apoptosis
    Qi, Shaohua
    Wu, Dongcheng
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 32 (06) : 1262 - 1272
  • [28] Protective effect of bone marrow mesenchymal stem cell-derived exosomes against the reproductive toxicity of cyclophosphamide is associated with the p38MAPK/ERK and AKT signaling pathways
    Guo, Xiao-Bin
    Zhai, Jia-Wen
    Xia, Hui
    Yang, Jian-Kun
    Zhou, Jun-Hao
    Guo, Wen-Bin
    Yang, Cheng
    Xia, Ming
    Xue, Kang-Yi
    Liu, Cun-Dong
    Zhou, Qi-Zhao
    ASIAN JOURNAL OF ANDROLOGY, 2021, 23 (04) : 386 - 391
  • [29] Protective effect of miR-20a against hypoxia/reoxygenation treatment on cardiomyocytes cell viability and cell apoptosis by targeting TLR4 and inhibiting p38 MAPK/JNK signaling
    Xin-Yu Gong
    Yun Zhang
    In Vitro Cellular & Developmental Biology - Animal, 2019, 55 : 793 - 800
  • [30] Protective effect of miR-20a against hypoxia/reoxygenation treatment on cardiomyocytes cell viability and cell apoptosis by targeting TLR4 and inhibiting p38 MAPK/JNK signaling
    Gong, Xin-Yu
    Zhang, Yun
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2019, 55 (10) : 793 - 800
12345