Modification of folded proteins at will, within any sequence context, remains an elusive goal. A proteome-wide screening approach has now identified a set of protein ligases that enables conjugation of peptides to almost any protein N terminus, overcoming longstanding limitations in protein engineering.
机构:
IVI Fdn, Inst Invest Sanitaria La Fe, Ave Fernando Abril Martorell 106, Valencia, SpainIVI Fdn, Inst Invest Sanitaria La Fe, Ave Fernando Abril Martorell 106, Valencia, Spain