Easy Strategy for the Synthesis of New 5,6-Dihydro-[1,2,4]triazolo[4,3-a][1,3,5]triazine Derivatives

被引：0
|
作者：
A. Hajri
L. Marzouki
机构：
[1] University of Jendouba,Laboratory of Functional Physiology and Valuation of Bio
来源：
Russian Journal of Organic Chemistry | 2019年 / 55卷
关键词：
1,2,4-triazoles; amidines; 5,6-dihydro[1,2,4]triazolo[4,3-; ][1,3,5]triazines; aldehydes; ketones;
D O I：
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中图分类号：
学科分类号：
摘要：
New substituted 5,6-dihydro[1,2,4]triazolo[4,3-a][1,3,5]triazines were synthesized by cyclocondensation of N-alkyl(aryl)-N′-(4H-1,2,4-triazol-3-yl)ethan- and -propanimidamides with benzaldehyde or ethyl methyl ketone in the presence of p-toluenesulfonic acid in 1,4-dioxane under reflux. The reaction tolerated a broad substrate scope and provided good yields (43–64%). The structure of the newly synthesized compounds was confirmed by elemental analyses and IR, 1H and 13C NMR, and mass spectra.
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页码：1394 / 1398
页数：4
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