Effect of dehydroepiandrosterone on radioligand binding of [3H]-testosterone by androgen receptors in rat hypothalamus

被引：0
|
作者：
Bairamov A.A. [1 ]
Sapronov N.S. [1 ]
机构：
[1] Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg
来源：
Bulletin of Experimental Biology and Medicine | 2004年 / 138卷 / 4期
关键词：
Androgen receptors; Dehydroepiandrosterone; Gonadectomy; Hypothalamus;
D O I：
10.1007/s10517-005-0107-7
中图分类号：
学科分类号：
摘要：
Intramuscular injections of dehydroepiandrosterone in a dose of 0.7 mg/kg for 10 days significantly increased nuclear and cytoplasmic fractions of androgen receptors in the preoptic/anterior hypothalamic area. Presumably, the effect of the neurosteroid is mediated by 5α-reductase transformation of dehydroepiandrosterone into 5α-dehydroepiandrosterone, which initiates the synthesis of androgen receptors. © Springer Science+Business Media, Inc. 2004.
引用
收藏
页码：387 / 389
页数：2
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