Loss of 22q Chromosome is Related to Glioma Progression and Loss of 10q

被引：0
|
作者：
Florence Laigle-Donadey
Emmanuelle Crinière
Alexandra Benouaich
Emmanuelle Lesueur
Karima Mokhtari
Khe Hoang-Xuan
Marc Sanson
机构：
[1] Groupe hospitalier Pitié-Salpétrière,Fédération de neurologie Mazarin
[2] Université Paris P et M Curie,Laboratoire de Neuropathologie, Groupe hospitalier Pitié
[3] Unité mixte de recherche,Salpêtrière
[4] U711 INSERM,undefined
[5] Université Paris P et M Curie,undefined
来源：
Journal of Neuro-Oncology | 2006年 / 76卷
关键词：
chromosome 10q; chromosome 22q; glioma;
D O I：
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中图分类号：
学科分类号：
摘要：
Loss of heterozygosity (LOH) of chromosome 22q has been investigated in 160 gliomas. LOH at one or more microsatellite increased with increasing grade of the tumor (P < 0.01). LOH22q was more frequent in astrocytic tumors (37%) compared to mixed or oligodendroglial tumors (21%) (P = 0.02). LOH22q was correlated to 10q loss but not to 1p or 9p loss. Taken together, these data suggest that LOH22q is an alteration associated with malignant progression of gliomas.
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页码：265 / 268
页数：3
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