Deciphering the focal role of endostatin in Alzheimer's disease

被引:1
|
作者
Kaur, Dapinder [1 ]
Behl, Tapan [1 ]
Chigurupati, Sridevi [2 ]
Sehgal, Aayush [1 ]
Singh, Sukhbir [1 ]
Sharma, Neelam [1 ]
Badavath, Vishnu Nayak [1 ]
Vargas-De-La-Cruz, Celia [3 ,4 ]
Bhatia, Saurabh [5 ,6 ]
Al-Harrasi, Ahmed [5 ]
Dey, Abhijit [7 ]
Aleya, Lotfi [8 ]
Bungau, Simona [9 ]
机构
[1] Chitkara Univ, Chitkara Coll Pharm, Chandigarh, Punjab, India
[2] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah, Saudi Arabia
[3] Univ Nacl Mayor San Marcos, Acad Dept Pharmacol Bromatol & Toxicol, Fac Pharm & Biochem, Ctr Latinoamer Ensenanza & Invest Bacteriol Alime, Lima, Peru
[4] Univ Ciencias & Humanidades, E Hlth Res Ctr, Lima, Peru
[5] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman
[6] Univ Petr & Energy Studies, Sch Hlth Sci, Dehra Dun, Uttarakhand, India
[7] Presidency Univ, Dept Life Sci, Kolkata, India
[8] Bourgogne Franche Comte Univ, Chronoenvironm Lab, UMR CNRS 6249, Besancon, France
[9] Univ Oradea, Fac Pharm, Dept Pharm, Oradea, Romania
关键词
Alzheimer's disease; Endostatin; Angiogenesis; Pro-angiogenic factors; Antiangiogenic factors; Collagen XVIII; BLOOD-BRAIN-BARRIER; ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS INHIBITOR ENDOSTATIN; VASCULAR RISK-FACTORS; HEPARAN-SULFATE; CEREBROSPINAL-FLUID; APOLIPOPROTEIN-E; CELL MIGRATION; IN-VITRO; VEGF;
D O I
10.1007/s11356-021-16567-7
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Alzheimer's disease (AD) is a paramount chronic neurodegenerative condition that has been affecting elderly people since the 1900s. It causes memory loss, disorientation, and poor mental function. AD is considered to be one of the most serious problems that dementia sufferers face. Despite extensive investigation, the pathological origin of Alzheimer's disease remains a mystery. The amyloid cascade theory and the vascular hypothesis, which stresses the buildup of A beta plaques, have dominated research into dementia and aging throughout history. However, research into this task failed to yield the long-awaited therapeutic miracle lead for Alzheimer's disease. Perhaps a hypothetical fragility in the context of Alzheimer's disease was regarded as a state distinct from aging in general, as suggested by the angiogenesis hypothesis, which suggests that old age is one state associated with upregulation of angiogenic growth factors, resulting in decreased microcirculation throughout the body. There has also been evidence that by controlling or inhibiting the components involved in the sequence of events that cause angiogenesis, there is a visible progression in AD patients. In Alzheimer's disease, one such antiangiogenic drug is being used.
引用
收藏
页码:61998 / 62011
页数:14
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