Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives

被引：0
|
作者：
N. Polkam
S. Malthum
J. S. Anireddy
U. Brahma
G. M. Naidu Vegi
机构：
[1] Jawaharlal Nehru Technological University Hyderabad,Centre for Chemical Sciences and Technology, Institute of Science and Technology
[2] Kukatpally,Department of Pharmacology and Toxicology
[3] National Institute of Pharmaceutical Education and Research,undefined
来源：
Russian Chemical Bulletin | 2021年 / 70卷
关键词：
1,3,4-oxadiazoles; 2,5-dimethoxyphenyl; anticancer agents; MTT assay; thioethers; sulfides;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of new 1,3,4-oxadiazole derivatives bearing the 2-positioned 2,5-dimethoxyphenyl substituent and 5-positioned organylsulfanyl moiety were designed and synthesized. Screening for anticancer activity against an array of human cancer cells revealed the superior activity of 2-(2,5-dimethoxyphenyl)-5-propylthio-1,3,4-oxadiazole. 2-(2,5-Dimethoxyphenyl)-5-butylthio-1,3,4-oxadiazole displayed excellent activity against breast cancer cell lines.
引用
收藏
页码：580 / 584
页数：4
相关论文
共 50 条
  • [31] SYNTHESIS OF SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES
    Mickevicius, V.
    Vaickelioniene, R.
    Sapijanskaite, B.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (02) : 215 - 218
  • [32] Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents
    Du, Qian-Ru
    Li, Dong-Dong
    Pi, Ya-Zhou
    Li, Jing-Ran
    Sun, Jian
    Fang, Fei
    Zhong, Wei-Qing
    Gong, Hai-Bin
    Zhu, Hai-Liang
    BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (08) : 2286 - 2297
  • [33] Design, Synthesis, and Antibacterial Activity of Novel Vanillic Acid Derivatives Incorporating 1,3,4-Oxadiazole and Thioether Moieties
    Yaxin Liu
    Boxi Tan
    Can He
    Shuangxue Wu
    Lu Yu
    Pei Li
    Russian Journal of General Chemistry, 2025, 95 (2) : 505 - 510
  • [34] NEW MESOGENIC 1,3,4-OXADIAZOLE DERIVATIVES
    GIRDZIUNAITE, D
    TSCHIERSKE, C
    NOVOTNA, E
    KRESSE, H
    HETZHEIM, A
    LIQUID CRYSTALS, 1991, 10 (03) : 397 - 407
  • [35] Novel pyrethrin derivatives containing hydrazone and 1,3,4-oxadiazole thioether moieties: Design, synthesis, and insecticidal activity
    Yang, Zai-Bo
    Li, Pei
    He, Yin-Ju
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2020, 195 (08) : 614 - 619
  • [36] Design and synthesis of pyrazole, pyrazolone and 1,3,4-oxadiazole derivatives having pyrrole motif as a source of new antimicrobial and anticancer
    Rawat, Poonam
    Bharati, Poonam
    Gautam, Anshu
    Kumar, Mukesh
    Singh, Riya
    Prakash, Anant
    Ram, Anant
    Gautam, Shipra
    Darwari, Amul
    Mishra, Akanksha
    Singh, R. N.
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1272
  • [37] Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives
    Fuqiang Yu
    Aiying Guan
    Mengru Li
    Lan Hu
    Xiaowu Li
    Chinese Chemical Letters, 2018, 29 (06) : 915 - 918
  • [38] Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives
    Yu, Fuqiang
    Guan, Aiying
    Li, Mengru
    Hu, Lan
    Li, Xiaowu
    CHINESE CHEMICAL LETTERS, 2018, 29 (06) : 915 - 918
  • [39] Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies
    Alam, Mohammad Mahboob
    Nazreen, Syed
    Almalki, Abdulraheem S. A.
    Elhenawy, Ahmed A.
    Alsenani, Nawaf, I
    Elbehairi, Serag Eldin, I
    Malebari, Azizah M.
    Alfaifi, Mohammad Y.
    Alsharif, Meshari A.
    Alfaifi, Sulaiman Y. M.
    PHARMACEUTICALS, 2021, 14 (09)
  • [40] Synthesis and Biological Evaluation of 1,3,4-Oxadiazole Derivatives as Acetylcholinesterase Inhibitors
    Shun Yang
    Jing-Pei Zou
    Xiang-Rong Li
    Rui Li
    Jing-Jing Qian
    Wen-Long Wu
    Jia-Bin Su
    Ke-Qi Chen
    Tian Qin
    Shan-Ming Liu
    Wei-Wei Liu
    Da-Hua Shi
    Russian Journal of Organic Chemistry, 2022, 58 : 1520 - 1526
12345