Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives

被引：0
|
作者：
N. Polkam
S. Malthum
J. S. Anireddy
U. Brahma
G. M. Naidu Vegi
机构：
[1] Jawaharlal Nehru Technological University Hyderabad,Centre for Chemical Sciences and Technology, Institute of Science and Technology
[2] Kukatpally,Department of Pharmacology and Toxicology
[3] National Institute of Pharmaceutical Education and Research,undefined
来源：
Russian Chemical Bulletin | 2021年 / 70卷
关键词：
1,3,4-oxadiazoles; 2,5-dimethoxyphenyl; anticancer agents; MTT assay; thioethers; sulfides;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of new 1,3,4-oxadiazole derivatives bearing the 2-positioned 2,5-dimethoxyphenyl substituent and 5-positioned organylsulfanyl moiety were designed and synthesized. Screening for anticancer activity against an array of human cancer cells revealed the superior activity of 2-(2,5-dimethoxyphenyl)-5-propylthio-1,3,4-oxadiazole. 2-(2,5-Dimethoxyphenyl)-5-butylthio-1,3,4-oxadiazole displayed excellent activity against breast cancer cell lines.
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页码：580 / 584
页数：4
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