Expected effects of mass screening policies on the frequency of cystic fibrosis homozygotes

被引:0
|
作者
Giorgio Bertorelle
G. Barbujani
机构
[1] Dipartimento di Biologia,
[2] Università di Padova,undefined
[3] Padova,undefined
[4] Italy,undefined
[5] Dipartimento di Biologia,undefined
[6] Università di Ferrara,undefined
[7] Via L. Borsari 46,undefined
[8] I-44100 Ferrara,undefined
[9] Italy Tel.: +39-532-291312; Fax: +39-532-249761 e-mail: bjg@ifeuniv.unife.it,undefined
来源
Human Genetics | 1997年 / 100卷
关键词
Cystic Fibrosis; Screening Programme; Selection Mechanism; Directional Selection; Expected Effect;
D O I
暂无
中图分类号
学科分类号
摘要
We evaluated, by deterministic computer simulation, some effects of a screening programme for carriers of cystic fibrosis mutations. Two different selective regimes (heterozygote advantage and directional selection against recessive homozygotes) and three kinds of response to the screening were simulated. The curves describing the expected decline in the frequency of CF homozygotes allow one to predict some benefits of a screening campaign. In addition, it is shown that a strategy aimed at testing couples, rather than individuals, may become less expensive after only two generations of screening. The main source of uncertainty for a screening programme remains the selection mechanism, namely the existence of some sort of biological advantage for heterozygous carriers of CF mutations.
引用
收藏
页码:666 / 668
页数:2
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