Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer’s disease pathology: a population-based autopsy study in an admixed sample

被引:0
|
作者
Regina Silva Paradela
Alberto Fernando Oliveira Justo
Vítor Ribeiro Paes
Renata E. P. Leite
Carlos A. Pasqualucci
Lea T. Grinberg
Michel Satya Naslavsky
Mayana Zatz
Ricardo Nitrini
Wilson Jacob-Filho
Claudia Kimie Suemoto
机构
[1] University of São Paulo Medical School,Division of Geriatrics
[2] University of Sao Paulo Medical School,Department of Pathology
[3] University of California,Memory and Aging Center
[4] University of São Paulo,Human Genome and Stem Cell Center, Biosciences Institute
[5] University of São Paulo Medical School,Department of Neurology
关键词
Apolipoprotein E; Cognition; Dementia; Neuritic plaques; Neurofibrillary tangles; Mediation analysis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Association of Anticholinergic Use with Incidence of Alzheimer’s Disease: Population-based Cohort Study
    Kyung-in Joung
    Sukil Kim
    Yoon Hee Cho
    Sung-il Cho
    Scientific Reports, 9
  • [22] Association of Anticholinergic Use with Incidence of Alzheimer's Disease: Population-based Cohort Study
    Joung, Kyung-in
    Kim, Sukil
    Cho, Yoon Hee
    Cho, Sung-il
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [23] Association Between the APOE ε2/ε4 Genotype and Alzheimer's Disease and Mild Cognitive Impairment Among African Americans
    Ren, Dianxu
    Lopez, Oscar L.
    Lingler, Jennifer H.
    Conley, Yvette
    JOURNAL OF ALZHEIMERS DISEASE, 2021, 81 (03) : 943 - 948
  • [24] A 9-Year Prospective Population-Based Study on the Association Between the APOE*E4 Allele and Late-Life Depression in Sweden
    Skoog, Ingmar
    Waern, Margda
    Duberstein, Paul
    Blennow, Kaj
    Zetterberg, Henrik
    Borjesson-Hanson, Anne
    Ostling, Svante
    Guo, Xinxin
    Kern, Jurgen
    Gustafson, Deborah
    Gudmundsson, Pia
    Marlow, Thomas
    Kern, Silke
    BIOLOGICAL PSYCHIATRY, 2015, 78 (10) : 730 - 736
  • [25] Plasma levels of antioxidants are not associated with Alzheimer's disease or cognitive decline - A population-based study
    Engelhart, MJ
    Ruitenberg, A
    Meijer, J
    Kiliaan, A
    van Swieten, JC
    Hofman, A
    Witteman, JCM
    Breteler, MMB
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2005, 19 (2-3) : 134 - 139
  • [26] Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study
    Hong, Chien-Tai
    Chan, Lung
    Wu, Dean
    Chen, Wan-Ting
    Chien, Li-Nien
    FRONTIERS IN NEUROLOGY, 2019, 10
  • [27] Association Between Nap and Reported Cognitive Function and Role of Sleep Debt: A Population-Based Study
    Chang, Hee Jin
    Yang, Kwang Ik
    Chu, Min Kyung
    Yun, Chang-Ho
    Kim, Daeyoung
    JOURNAL OF CLINICAL NEUROLOGY, 2022, 18 (04): : 470 - 477
  • [28] Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan
    Yi-Hua Sun
    Oswald Ndi Nfor
    Jing-Yang Huang
    Yung-Po Liaw
    Alzheimer's Research & Therapy, 7
  • [29] Association between chronic periodontitis and the risk of Alzheimer's disease: a retrospective, population-based, matched-cohort study
    Chen, Chang-Kai
    Wu, Yung-Tsan
    Chang, Yu-Chao
    ALZHEIMERS RESEARCH & THERAPY, 2017, 9
  • [30] Association between normal tension glaucoma and the risk of Alzheimer's disease: a nationwide population-based cohort study in Taiwan
    Chen, Yu-Yen
    Lai, Yun-Ju
    Yen, Yung-Feng
    Shen, Ying-Cheng
    Wang, Chun-Yuan
    Liang, Chiao-Ying
    Lin, Keng-Hung
    Fan, Lir-Wan
    BMJ OPEN, 2018, 8 (11):