In vitro effects of anti-Trypanosoma cruzi compounds on HSP60 levels

被引：2
|
作者：
Muelas-Serrano S. [1 ]
Pérez-Serrano J. [3 ]
Gómez-Barrio A. [1 ]
Ochoa C. [2 ]
Martínez J. [3 ]
Rodríguez-Caabeiro F. [3 ]
机构：
[1] Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Ciudad Universitaria s/n
[2] Instituto de Química Médica, Consejo Superior de Investigaciones Científicas, 28003 Madrid
[3] Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Alcalá
来源：
Parasitology Research | 2001年 / 87卷 / 8期
关键词：
HSP60 Level; Nifurtimox; HSP60 Immunoreactivity; Cruzi Activity;
D O I：
10.1007/s004360100422
中图分类号：
学科分类号：
摘要：
The effect of nifurtimox and 5-nitro-2-thienylmalononitrile (5NO2TM), a novel compound with anti-Trypanosoma cruzi activity, upon vitality and HSP60 immunoreactivity of epimastigotes, has been determined. Both products showed no activity against epimastigotes at 0.1 μg/ml, while at 0.5 and 1 μg/ml, after 24 h of incubation, densities of these groups were significantly reduced, when compared to controls. An enhancement of HSP60 immunoreactivity was observed after 24 h in groups treated with 0.5 and 1 μg/ml nifurtimox. On the other hand, 5NO2TM had no effect.
引用
收藏
页码：615 / 618
页数：3
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