Serum or plasma is frequently utilized in biomedical research; however, its application is impeded by the requirement for invasive sample collection. The non-invasive nature of urine collection makes it an attractive alternative for disease characterization and biomarker discovery. Mass spectrometry-based protein profiling of urine has led to the discovery of several disease-associated biomarkers. Proteomic analysis of urine has not only been applied to disorders of the kidney and urinary bladder but also to conditions affecting distant organs because proteins excreted in the urine originate from multiple organs. This review provides a progress update on urinary proteomics carried out over the past decade. Studies summarized in this review have expanded the catalog of proteins detected in the urine in a variety of clinical conditions. The wide range of applications of urine analysis—from characterizing diseases to discovering predictive, diagnostic and prognostic markers—continues to drive investigations of the urinary proteome.
机构:
Manipal Acad Higher Educ MAHE, Manipal 576104, India
Int Technol Pk, Inst Bioinformat, Bangalore 560066, India
Mayo Clin, Dept Lab Med & Pathol, 200 First St SW, Rochester, MN 55905 USAManipal Acad Higher Educ MAHE, Manipal 576104, India
Joshi, Neha
Garapati, Kishore
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Manipal Acad Higher Educ MAHE, Manipal 576104, India
Int Technol Pk, Inst Bioinformat, Bangalore 560066, India
Mayo Clin, Dept Lab Med & Pathol, 200 First St SW, Rochester, MN 55905 USAManipal Acad Higher Educ MAHE, Manipal 576104, India
Garapati, Kishore
Ghose, Vivek
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Manipal Acad Higher Educ MAHE, Manipal 576104, India
Int Technol Pk, Inst Bioinformat, Bangalore 560066, IndiaManipal Acad Higher Educ MAHE, Manipal 576104, India
Ghose, Vivek
Kandasamy, Richard K.
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Mayo Clin, Dept Lab Med & Pathol, 200 First St SW, Rochester, MN 55905 USA
Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN 55905 USA
Mayo Clin, Ctr Individualized Med, Rochester, MN 55905 USAManipal Acad Higher Educ MAHE, Manipal 576104, India
Kandasamy, Richard K.
Pandey, Akhilesh
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机构:
Int Technol Pk, Inst Bioinformat, Bangalore 560066, India
Mayo Clin, Dept Lab Med & Pathol, 200 First St SW, Rochester, MN 55905 USA
Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN 55905 USA
Mayo Clin, Ctr Individualized Med, Rochester, MN 55905 USAManipal Acad Higher Educ MAHE, Manipal 576104, India
机构:
Department of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology
Changwon Kang
Yejin Lee
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Center for Bioanalysis, Korea Research Institute of Standards and ScienceDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology
Yejin Lee
J Eugene Lee
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Center for Bioanalysis, Korea Research Institute of Standards and ScienceDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology