Synthesis and evaluation of new 2,6-diamino-5-hetarylpyrimidines as inhibitors of dihydrofolate reductase

被引：0
|
作者：
Olga V. Khilya
Demyd S. Milokhov
Lyudmyla A. Kononets
Oleksandr L. Kobzar
Andriy I. Vovk
Yulian M. Volovenko
机构：
[1] Taras Shevchenko National University of Kyiv,Chemistry Department
[2] Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine,Department of Bioorganic Mechanisms
来源：
Monatshefte für Chemie - Chemical Monthly | 2018年 / 149卷
关键词：
2,6-Diaminopyrimidine; Ring transformation reaction; Cyclizations; Nucleophilic additions; Dihydrofolate reductase; Inhibition;
D O I：
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学科分类号：
摘要：
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页码：813 / 822
页数：9
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