Phosphatidylinositol- 3-kinase inhibitor induces chemosensitivity to a novel derivative of doxorubicin, AD198 chemotherapy in human bladder cancer cells in vitro

被引：0
|
作者：
Dmitriy Smolensky
Kusum Rathore
Maria Cekanova
机构：
[1] College of Veterinary Medicine,Department of Small Animal Clinical Sciences
[2] The University of Tennessee,undefined
[3] UT-ORNL Graduate School of Genome Science and Technology,undefined
[4] The University of Tennessee,undefined
来源：
BMC Cancer | / 15卷
关键词：
Doxorubicin; AD198; Bladder cancer; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 37 条
  • [21] ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells
    Wang, Yaochen
    Liu, Jing
    Qiu, Yuling
    Jin, Meihua
    Chen, Xi
    Fan, Guanwei
    Wang, Ran
    Kong, Dexin
    ONCOTARGET, 2016, 7 (15) : 19897 - 19909
  • [22] The EGER tyrosine kinase inhibitor erlotinib induces cell cycle arrest and apoptosis in human hepatocellular cancer cells and enhances chemosensitivity to doxorubicin, docetaxel, and SN-38
    Huether, A
    Höpfner, M
    Sutter, AP
    Grabowski, P
    Schuppan, D
    Zeitz, M
    Scherübl, H
    GASTROENTEROLOGY, 2005, 128 (04) : A294 - A294
  • [23] The EGFR tyrosine kinase inhibitor erlotinib induces cell cycle arrest and apoptosis in human hepatocellular cancer cells and enhances chemosensitivity to doxorubicin, docetaxel, and SN-38
    Huether, A
    Höpfner, M
    Sutter, AP
    Grabowski, P
    Schuppan, D
    Zeitz, M
    Scherübl, H
    JOURNAL OF HEPATOLOGY, 2005, 42 : 128 - 128
  • [24] Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
    Chen, Hanyu
    Sheng, Hongqing
    Zhao, Yushuo
    Zhu, Guanghui
    MEDICAL SCIENCE MONITOR, 2020, 26
  • [25] RNA Interference-Mediated Silencing of the Phosphatidylinositol 3-Kinase Catalytic Subunit Attenuates Growth of Human Ovarian Cancer Cells in vitro and in vivo
    Zhang, Xi
    Deng, Hong-xin
    Zhao, Xia
    Su, Dan
    Chen, Xian-chen
    Chen, Li-juan
    Wei, Yu-quan
    Zhong, Qian
    Li, Zheng-yu
    He, Xiang
    Yi, Tao
    ONCOLOGY, 2009, 77 (01) : 22 - 32
  • [26] Targeted inhibition of Polo-like kinase 1 by a novel small-molecule inhibitor induces mitotic catastrophe and apoptosis in human bladder cancer cells
    Zhang, Zhe
    Zhang, Guojun
    Kong, Chuize
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2017, 21 (04) : 758 - 767
  • [27] In vitro anti-cancer activity of PF-04691502, a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) in a panel of human breast cancer cell lines
    Britten, Carolyn D.
    Chow, Lucy
    Conklin, Dylan
    Kalous, Ondrej
    Desai, Amrita
    Ginther, Charles
    Dering, Judy
    Christensen, James
    Milham, Robert
    Slamon, Dennis J.
    Finn, Richard S.
    CANCER RESEARCH, 2010, 70
  • [28] CAL-101, a Selective Inhibitor of the p110δ Isoform of Phosphatidylinositol 3-Kinase, Effectively Induces Apoptosis in Primary Chronic Lymphocytic Leukemia Cells Providing a Novel Therapeutic Strategy for the Treatment of This Disease
    May, Sarah E.
    Kashishian, Adam
    Lin, Thomas S.
    Jones, Jeffrey A.
    Flynn, Joseph M.
    Ulrich, Roger G.
    Chen, Hao
    Yu, Albert S.
    Puri, Kamal D.
    Lannutti, Brian J.
    Giese, Neill A.
    Byrd, John C.
    Johnson, Amy J.
    BLOOD, 2008, 112 (11) : 1085 - 1086
  • [29] Novel Phosphoinositide 3-Kinase/mTOR Dual Inhibitor, NVP-BGT226, Displays Potent Growth-Inhibitory Activity against Human Head and Neck Cancer Cells In Vitro and In Vivo
    Chang, Kwang-Yu
    Tsai, Shan-Yin
    Wu, Ching-Ming
    Yen, Chia-Jui
    Chuang, Bin-Fay
    Chang, Jang-Yang
    CLINICAL CANCER RESEARCH, 2011, 17 (22) : 7116 - 7126
  • [30] Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells
    Izutani, Yasuyuki
    Yogosawa, Shingo
    Sowa, Yoshihiro
    Sakai, Toshiyuki
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 40 (03) : 816 - 824
1234