The role of liver kinase B1 in tumor progression through regulation of lipid metabolism

被引：0
|
作者：
Jialu Geng
Yanghe Zhang
Qingfei Meng
Hang Yan
Yishu Wang
机构：
[1] Jilin University,Key Laboratory of Pathobiology, Ministry of Education
来源：
Clinical and Translational Oncology | 2022年 / 24卷
关键词：
LKB1; Lipid metabolism; Tumor; AMPK;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The somatic mutation of liver kinase B1 (LKB1) has been implicated in various tumors, which is reflected in the survival, proliferation, and metastasis of tumor cells. However, the regulation of LKB1 in lipid metabolism, a process that is involved in tumor progression is not completely clear. We conclude that LKB1 deficiency results in abnormal expression and activation of multiple molecules related to lipid metabolism which locate downstream of AMP-activated protein kinase (AMPK) or salt-induced kinase (SIK). Abnormal lipid metabolism induced by LKB1 deficiency contributes to the proliferation and metastasis of tumor cells through energy regulation.
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收藏
页码：2045 / 2054
页数：9
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