Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis

被引：0
|
作者：
Roberto Salvi
Veronique Péclat
Alexander So
Nathalie Busso
机构：
[1] Centre Hospitalier Universitaire Vaudois,Laboratoire de Rhumatologie
来源：
Arthritis Research & Therapy | / 2卷
关键词：
arthritis; coagulation; fibrinolysis; mice; RNase protection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased expression of tissue factor, tissue factor pathway inhibitor, urokinase plasminogen activator, and plasminogen activator inhibitor 1, as well as thrombin receptor. The observed pattern of gene expression tended to favor procoagulant activity, and this pattern was confirmed by functional assays. These alterations would account for persistence of fibrin within the inflamed joint, as is seen in rheumatoid arthritis.
引用
收藏
相关论文
共 50 条
  • [41] Disseminated Intravascular Coagulation with Enhanced Fibrinolysis Caused by Heart Metastasis of Bladder Urothelial Carcinoma
    Helal, Clara
    Lambert, Tiphaine
    Joly, Berangere S.
    Dumont, Clement
    Gauthier, Helene
    Culine, Stephane
    CASE REPORTS IN ONCOLOGY, 2022, 15 (02): : 745 - 749
  • [42] An enhanced fibrinolysis prevents the development of multiple organ failure in disseminated intravascular coagulation in spite of much activation of blood coagulation
    Asakura, H
    Ontachi, Y
    Mizutani, T
    Kato, M
    Saito, M
    Kumabashiri, I
    Morishita, E
    Yamazaki, M
    Aoshima, K
    Nakao, S
    CRITICAL CARE MEDICINE, 2001, 29 (06) : 1164 - 1168
  • [43] A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis
    Chung, YL
    Lee, MY
    Wang, AJ
    Yao, LF
    MOLECULAR THERAPY, 2003, 8 (05) : 707 - 717
  • [44] Gene expression profiling provides insights into the pathways involved in inflammatory arthritis development: Murine model of Lyme disease
    Miller, Jennifer C.
    Ma, Ying
    Crandall, Hillary
    Wang, Xiaohui
    Weis, Janis J.
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2008, 85 (01) : 20 - 27
  • [45] Coagulation- and fibrinolysis-related genes for predicting survival and immunotherapy efficacy in colorectal cancer
    Ma, Yanling
    Wang, Bofang
    He, Puyi
    Qi, Wenbo
    Xiang, Ling
    Maswikiti, Ewetse Paul
    Chen, Hao
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [46] Variation in coagulation and fibrinolysis genes evaluated for their contribution to cerebrovascular complications in adults with bacterial meningitis in the Netherlands
    Kloek, A. T.
    Khan, H. N.
    Seron, M. Valls
    Jongejan, A.
    Zwinderman, A. H.
    Baas, F.
    van der Ende, A.
    van de Beek, D.
    Ferwerda, B.
    Brouwer, M. C.
    JOURNAL OF INFECTION, 2018, 77 (01) : 54 - 59
  • [47] The contribution of variation in coagulation and fibrinolysis genes to cerebrovascular complications in community-acquired bacterial meningitis
    Kloek, A.
    Khan, H.
    Seron, M. Valls
    Jongejan, A.
    Zwinderman, K.
    Baas, F.
    van der Ende, A.
    van de Beek, D.
    Ferwerda, B.
    Brouwer, M.
    EUROPEAN JOURNAL OF NEUROLOGY, 2018, 25 : 414 - 414
  • [48] Chromosomal arrangement of the murine coagulation factor VII and factor X genes
    Liang, Z
    Cooper, A
    Rosen, ED
    Castellino, FJ
    THROMBOSIS AND HAEMOSTASIS, 1998, 80 (03) : 524 - 525
  • [49] Enhanced local expression of cartilage-degrading ADAMTS proteases in murine collagen-induced arthritis
    Lauer, G
    Motz, C
    Barsig, J
    ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 : 139 - 139
  • [50] Mapping of genes involved in murine herpes simplex virus keratitis: Identification of genes and their modifiers
    Norose, K
    Yano, A
    Zhang, XM
    Blankenhorn, E
    Heber-Katz, E
    JOURNAL OF VIROLOGY, 2002, 76 (07) : 3502 - 3510
12345