Association of VNTR Polymorphism of the AS3MT Gene with the Risk of Schizophrenia

被引：0
|
作者：
G. I. Korovaitseva
T. V. Lezheiko
I. V. Oleichik
V. E. Golimbet
机构：
[1] Mental Health Research Center,
来源：
Russian Journal of Genetics | 2023年 / 59卷
关键词：
VNTR polymorphism; gene; schizophrenia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The AS3MT gene encodes arsenic(III) methyltransferase. VNTR polymorphism of the AS3MT gene is characteristic only for the human genome. It is associated with the expression of a human-specific AS3MTd2d3 protein isoform, which is a potential risk factor for the development of schizophrenia. In this study, we have analyzed for the first time the distribution of frequencies of alleles and genotypes of VNTR polymorphism in a large sample of ethnic Russians. The association of VNTR with the risk of schizophrenia has been studied. This study included 1002 patients with schizophrenia and schizophrenia spectrum disorders and 1510 people of the control group. Women with the V3/V3 genotype have an increased risk of schizophrenia (OR = 1.4, 95% CI: 1.11–1.77).
引用
收藏
页码：414 / 418
页数：4
相关论文
共 50 条
  • [1] Association of VNTR Polymorphism of the AS3MT Gene with the Risk of Schizophrenia
    Korovaitseva, G. I.
    Lezheiko, T. V.
    Oleichik, I. V.
    Golimbet, V. E.
    RUSSIAN JOURNAL OF GENETICS, 2023, 59 (04) : 414 - 418
  • [2] Effect of VNTR Polymorphism of the AS3MT Gene and Obstetrical Complications on the Severity of Schizophrenia
    G. I. Korovaitseva
    M. V. Gabaeva
    O. A. Yunilainen
    V. E. Golimbet
    Bulletin of Experimental Biology and Medicine, 2019, 168 : 84 - 86
  • [3] Effect of VNTR Polymorphism of the AS3MT Gene and Obstetrical Complications on the Severity of Schizophrenia
    Korovaitseva, G. I.
    Gabaeva, M. V.
    Yunilainen, O. A.
    Golimbet, V. E.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2019, 168 (01) : 84 - 86
  • [4] Association Between Arsenic Toxicity, AS3MT Gene Polymorphism and Onset of Type 2 Diabetes
    Saima Shokat
    Riffat Iqbal
    Samreen Riaz
    Atif Yaqub
    Biological Trace Element Research, 2024, 202 : 1550 - 1558
  • [5] Association Between Arsenic Toxicity, AS3MT Gene Polymorphism and Onset of Type 2 Diabetes
    Shokat, Saima
    Iqbal, Riffat
    Riaz, Samreen
    Yaqub, Atif
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2024, 202 (04) : 1550 - 1558
  • [6] Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions
    Valenzuela, Olga L.
    Drobna, Zuzana
    Hernandez-Castellanos, Erika
    Sanchez-Pena, Luz C.
    Garcia-Vargas, Gonzalo G.
    Borja-Aburto, Victor H.
    Styblo, Miroslav
    Del Razo, Luz M.
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 239 (02) : 200 - 207
  • [7] AS3MT gene polymorphism in residents exposed to inorganic arsenic via drinking water
    Kadioglu, Ela
    Hisarli, N. Deniz
    Asik, Elif
    Demircigil, Gonca Cakmak
    Alshana, Usama
    Ertas, Nusret
    Celebi, Celalettin R.
    Atabey, Esref
    Ataman, O. Yavuz
    Serce, Hakan
    Bilir, Nazmi
    Tuncer, A. Murat
    Burgaz, Sema
    TOXICOLOGY LETTERS, 2012, 211 : S92 - S92
  • [8] Functional characterization of the schizophrenia associated gene AS3MT identifies a role in neuronal development
    Washer, Sam J.
    Flynn, Robert
    Oguro-Ando, Asami
    Hannon, Eilis
    Burrage, Joe
    Jeffries, Aaron
    Mill, Jonathan
    Dempster, Emma L.
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2022, 189 (05) : 151 - 162
  • [9] Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk
    Duan, Yin
    Pan, Chi
    Shi, Jinan
    Chen, Hailong
    Zhang, Suzhan
    CANCER CELL INTERNATIONAL, 2014, 14
  • [10] Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk
    Yin Duan
    Chi Pan
    Jinan Shi
    Hailong Chen
    Suzhan Zhang
    Cancer Cell International, 14
12345