Interaction among NMDA receptor-, NMDA glycine site- and AMPA receptor antagonists in spinally mediated analgesia

被引:0
|
作者
Tomoki Nishiyama
机构
[1] The University of Tokyo,From the Department of Anesthesiology
来源
关键词
NMDA; NMDA Receptor; AMPA Receptor; NMDA Receptor Antagonist; Excitatory Amino Acid Receptor;
D O I
暂无
中图分类号
学科分类号
摘要
Purpose: The NMDA (N-methyl-D-aspartate) receptor antagonists and the NMDA glycine site antagonists given alone have minimal effects on acute nociception. In contrast, the AMPA (alpha-amino-3-hydroxy-5-methylisoxa-zole-4-propionic acid) receptor antagonists have a major role in acute nociception. We investigated the interactions among these three antagonists in acute nociception.
引用
收藏
页码:693 / 698
页数:5
相关论文
共 50 条
  • [31] Combination of NMDA and AMPA receptor antagonists, and antinociception at the spinal level in rats
    Notsuka, H
    Hamada, F
    Benson, KT
    Totoki, T
    Goto, H
    [J]. ANESTHESIA AND ANALGESIA, 1998, 86 (2S): : U187 - U187
  • [32] EFFECT OF GLYCINE AND GLYCINE RECEPTOR ANTAGONISTS ON NMDA-INDUCED BRAIN INJURY
    UCKELE, JE
    MCDONALD, JW
    JOHNSTON, MV
    SILVERSTEIN, FS
    [J]. NEUROSCIENCE LETTERS, 1989, 107 (1-3) : 279 - 283
  • [33] The high variance of AMPA receptor- and NMDA receptor-mediated responses at single hippocampal synapses: Evidence for multiquantal release
    Conti, R
    Lisman, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (08) : 4885 - 4890
  • [34] The role of stacking interactions in the binding of the NMDA receptor glycine site with antagonists and 3-hydroxykynurenine
    Zakharov G.A.
    Popov A.V.
    Savvateeva-Popova E.V.
    Shchegolev B.F.
    [J]. Biophysics, 2008, 53 (1) : 8 - 14
  • [35] MODULATION OF THE NMDA RECEPTOR BY THE STRYCHNINE-INSENSITIVE GLYCINE SITE
    PEETERS, BWMM
    VANDERHEYDEN, PML
    [J]. NEUROPSYCHOPHARMACOLOGY, 1993, 9 (02) : S152 - S152
  • [36] Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site
    Seong S. Shim
    Michael D. Hammonds
    Baik S. Kee
    [J]. European Archives of Psychiatry and Clinical Neuroscience, 2007, 258 : 16 - 27
  • [37] THE NMDA RECEPTOR REDOX SITE CONTROLS NMDA-RECEPTOR-MEDIATED LONG-TERM POTENTIATION
    GOZLAN, H
    DIABIRA, D
    CHINESTRA, P
    BENARI, Y
    [J]. COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES, 1994, 317 (10): : 885 - 890
  • [38] REQUIREMENT OF GLYCINE FOR GLUTAMATE ACTIVITY AT THE NMDA RECEPTOR-SITE
    RATTI, E
    TACCONI, S
    GRAZIANI, F
    GAVIRAGHI, G
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (05) : 1665 - 1665
  • [39] ACTIVATION OF THE GLYCINE SITE IN THE NMDA RECEPTOR IS NECESSARY FOR THE INDUCTION OF LTP
    BASHIR, ZI
    TAM, B
    COLLINGRIDGE, GL
    [J]. NEUROSCIENCE LETTERS, 1990, 108 (03) : 261 - 266
  • [40] Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site
    Shim, Seong S.
    Hammonds, Michael D.
    Kee, Baik S.
    [J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2007, 258 (01) : 16 - 27