Aptamers in Research and Drug Development

被引：0
|
作者：
Günter Mayer
Andreas Jenne
机构：
[1] NascaCell IP GmbH,Kekulé
[2] Universität Bonn,Institut für Organische Chemie und Biochemie
来源：
BioDrugs | 2004年 / 18卷
关键词：
Target Validation; Pegaptanib; Human Neutrophil Elastase; Cetrorelix; Cellular Delivery;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aptamers are short single-stranded oligonucleotides that fold into well defined three-dimensional shapes allowing them to bind to and inhibit their targets with high affinity and specificity. Aptamers can be considered truly multifunctional tools, because they can be generated rapidly and applied for specific detection, inhibition, and characterization of proteins. Recent publications impressively confirm that aptamers can be used either as surrogate inhibitors for the identification of small molecule lead compounds or as biopharmaceuticals.
引用
收藏
页码：351 / 359
页数：8
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