Inhibitory Effect of Antisense Oligonucleotide Targeting TIMP-2 on Immune-Induced Liver Fibrosis

被引:0
|
作者
Qing-He Nie
Chuan-Long Zhu
Ya-Fei Zhang
Jie Yang
Jiu-Cong Zhang
Ren-Tao Gao
机构
[1] Fourth Military Medical University,Chinese PLA Centre of Diagnosis and Treatment for Infectious Diseases, Tangdu Hospital
[2] Affiliated Provincial Hospital of Anhui Medical University,Department of Infectious Disease
[3] Fourth Military Medical University,Institute of Digestive Diseases of PLA and State Key Laboratory of Cancer Biology, Xijing Hospital
来源
关键词
Antisense oligonucleotide; Tissue inhibitors of metalloproteinases; Liver fibrosis; Gene therapy; Model/rat;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1286 / 1295
页数:9
相关论文
共 50 条
  • [31] Application of TGF-β1, TIMP-1 and TIMP-2 small interfering RNAs can alleviate CCl4-induced hepatic fibrosis in rats by rebalancing Th1/Th2 cytokines
    Xue, Ying
    Qian, Keli
    Sun, Yinchun
    Xiao, Lang
    Shi, Xiaofeng
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021, 22 (03)
  • [32] Requirement for iNOS in chronic allergen exposure-induced pulmonary fibrosis but not inflammation or mucus production: Specific implications of TGF-b, TIMP-2, and arginase-2 expression
    Naura, Amarjit S.
    Zerfaoui, Mourad
    Kim, Hogyoung
    Hans, Chetan
    Ju, Jihang
    Rodriguez, Paulo C.
    Park, Jiwon
    Ochoa, Augusto C.
    Boulares, Hamid A.
    FASEB JOURNAL, 2010, 24
  • [33] Antitumor effect of G3139 Bcl-2 antisense oligonucleotide is independent of its immune stimulation by CpG motifs in SCID mice
    Wacheck, V
    Krepler, C
    Strommer, S
    Heere-Ress, E
    Klem, R
    Pehamberger, H
    Eichler, HG
    Jansen, B
    ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 2002, 12 (06): : 359 - 367
  • [34] Effect of IFN-α on CC14-Induced Fibrosis of the Liver and Immune Status in Mice of Different Age
    P. N. Filimonov
    T. G. Sukhenko
    N. I. Gavrilova
    V. A. Shkurupii
    Bulletin of Experimental Biology and Medicine, 2005, 139 : 324 - 327
  • [35] Effect of IFN-α on CC14-induced fibrosis of the liver and immune status in mice of different age
    Filimonov, PN
    Sukhenko, TG
    Gavrilova, NI
    Shkurupii, VA
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2005, 139 (03) : 324 - 327
  • [36] Inhibitory effect of silymarin on CCl4-induced liver fibrosis by reducing Ly6Chi monocytes infiltration
    Zhao, Xiang-An
    Chen, Guang-Mei
    Liu, Yong
    Chen, Yu-Xin
    Wu, Hong-Yan
    Chen, Jin
    Xiong, Ya-Li
    Tian, Chen
    Wang, Gui-Yang
    Jia, Bei
    Xia, Juan
    Wang, Jian
    Yan, Xiao-Min
    Zhang, Zhao-Ping
    Huang, Rui
    Wu, Chao
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (12): : 11941 - 11951
  • [37] Adenovirus-mediated knockdown of activin A receptor type 2A attenuates immune-induced hepatic fibrosis in mice and inhibits interleukin-17-induced activation of primary hepatic stellate cells
    Zhang, Hongjun
    Ju, Baoling
    Nie, Ying
    Song, Baohui
    Xu, Yuanhong
    Gao, Ping
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 42 (01) : 279 - 289
  • [38] Inhibitory Effect of Glutathione on Oxidative Liver Injury Induced by Dengue Virus Serotype 2 Infections in Mice
    Wang, Juan
    Chen, Yanlei
    Gao, Na
    Wang, Yisong
    Tian, Yanping
    Wu, Jiangman
    Zhang, Junlei
    Zhu, Junping
    Fan, Dongying
    An, Jing
    PLOS ONE, 2013, 8 (01):
  • [39] ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis
    Nalkurthi, Christina
    Schroder, Wayne A.
    Melino, Michelle
    Irvine, Katharine M.
    Nyuydzefe, Melanie
    Chen, Wei
    Liu, Jing
    Teng, Michele W. L.
    Hill, Geoffrey R.
    Bertolino, Patrick
    Blazar, Bruce R.
    Miller, Gregory C.
    Clouston, Andrew D.
    Zanin-Zhorov, Alexandra
    MacDonald, Kelli P. A.
    JHEP REPORTS, 2022, 4 (01)
  • [40] The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen α1(I), TIMP-1 and MMP-2
    Di Sario, A
    Bendia, E
    Macarri, G
    Candelaresi, C
    Taffetani, S
    Marzioni, M
    Omenetti, A
    De Minicis, S
    Trozzi, L
    Benedetti, A
    DIGESTIVE AND LIVER DISEASE, 2004, 36 (11) : 744 - 751