Towards targeting protein-protein interfaces with small molecules

被引:0
|
作者
Holger Gohlke
Alexander Metz
Christopher Pfleger
Dennis M Krüger
Sina Kazemi
机构
[1] Heinrich-Heine-University,Department of Mathematics and Natural Sciences
关键词
Binding Interface; Predictive Character; Protein Flexibility; Efficient Representation; Binding Epitope;
D O I
10.1186/1758-2946-3-S1-O21
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [11] Wrapping mimicking in drug-like small molecules disruptive of protein-protein interfaces
    Accordino, Sebastian R.
    Morini, Marcela A.
    Sierra, Maria Belen
    Fris, J. Ariel Rodriguez
    Appignanesi, Gustavo A.
    Fernandez, Ariel
    [J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2012, 80 (07) : 1755 - 1765
  • [12] Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database
    Higueruelo, Alicia P.
    Schreyer, Adrian
    Bickerton, G. Richard J.
    Pitt, Will R.
    Groom, Colin R.
    Blundell, Tom L.
    [J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2009, 74 (05) : 457 - 467
  • [13] Stabilization of protein-protein interactions by small molecules
    Giordanetto, Fabrizio
    Schafer, Anja
    Ottmann, Christian
    [J]. DRUG DISCOVERY TODAY, 2014, 19 (11) : 1812 - 1821
  • [14] Exploring Small Molecules Targeting Protein-Protein Interactions (PPIs): Advancements and Future Prospects
    Patil, Sachin P.
    [J]. PHARMACEUTICALS, 2023, 16 (12)
  • [15] Modulating protein-protein interactions with small molecules
    O' Connor, Cornelius J.
    Spring, David R.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [16] Small Molecules Targeting Protein-Protein Interactions: A Promising Anti-HIV Strategy
    Chimirri, Alba
    De Luca, Laura
    Ferro, Stefania
    Gitto, Rosaria
    Monforte, Anna Maria
    Agnello, Stefano
    Barreca, Maria Letizia
    Christ, Frauke
    Debyser, Zeger
    [J]. ANTIVIRAL RESEARCH, 2010, 86 (01) : A32 - A32
  • [17] How relevant is secondary structure mimicry in design of small molecules to disrupt protein-protein interfaces?
    Taechalertpaisarn, Jaru
    Araneillo, Maritess Noelle
    Lin, Chen-Ming
    Lyu, Rui-Liang
    Jiang, Zhengyang
    Perez, Lisa
    Loerger, Thomas
    Burgess, Kevin
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [18] Bioinformatics of Protein-Protein Interfaces and Small Molecule Effectors
    Walter, Peter
    Ulucan, Ozlem
    Metzger, Jennifer
    Helms, Volkhard
    [J]. CURRENT BIOINFORMATICS, 2012, 7 (02) : 159 - 172
  • [19] Editorial: Computational Drug Discovery for Targeting of Protein-Protein Interfaces
    Meli, Massimiliano
    Pandini, Alessandro
    Morra, Giulia
    [J]. FRONTIERS IN CHEMISTRY, 2021, 9
  • [20] Hot spots in protein-protein interfaces: Towards drug discovery
    Cukuroglu, Engin
    Engin, H. Billur
    Gursoy, Attila
    Keskin, Ozlem
    [J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2014, 116 (2-3): : 165 - 173