Discordant response of CD4+ T cells to antiretroviral therapy in HIV-infected patients coinfected with hepatitis C virus is accompanied by increased liver damage

被引：0
|
作者：
N. G. Shmagel
K. V. Shmagel
E. V. Saidakova
L. B. Korolevskaya
V. A. Chereshnev
机构：
[1] Perm State University,Institute of Ecology and Genetics of Microorganisms, Ural Branch
[2] Perm Regional Center for Protection against AIDS and Infectious Diseases,Institute of Immunology and Physiology, Ural Branch
[3] Russian Academy of Sciences,undefined
[4] Russian Academy of Sciences,undefined
[5] Yeltsin Ural Federal University,undefined
来源：
Doklady Biochemistry and Biophysics | 2015年 / 465卷
关键词：
Nucleoside Reverse Transcriptase Inhibitor; DOKLADY Biochemistry; Perm Regional; Becton Dickinson Immunocytometry System; Discordant Response;
D O I：
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中图分类号：
学科分类号：
摘要：
A study of HIV-infected patients coinfected with hepatitis C virus and receiving antiretroviral therapy (ART) but not treated with interferon was performed. Patients were divided into two groups—with standard and inefficient recovery of CD4+ T cells. It was found that patients with discordant response of CD4+ T cells to ART showed heavier destructive processes in the liver than the successfully recovered subjects. They had increased levels of ALT and AST. In these patients, the risk of development of liver cirrhosis is greater.
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页码：358 / 360
页数：2
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