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Southern Med Univ, Dept Pathogen Biol, Guangdong Prov Key Lab Trop Dis Res, Sch Publ Hlth, Guangzhou 510515, Peoples R China Southern Med Univ, Dept Pathogen Biol, Guangdong Prov Key Lab Trop Dis Res, Sch Publ Hlth, Guangzhou 510515, Peoples R China