The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals

被引：0
|
作者：
Sigrid Haeggström
Magnus Ingelman-Sundberg
Svante Pääbo
Hugo Zeberg
机构：
[1] Karolinska Institutet,Department of Neuroscience
[2] Karolinska Institutet,Department of Physiology and Pharmacology
[3] Max Planck Institute for Evolutionary Anthropology,Department of Evolutionary Genetics
[4] Okinawa Institute of Science and Technology,Human Evolutionary Genomics Unit
来源：
The Pharmacogenomics Journal | 2022年 / 22卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals.
引用
收藏
页码：247 / 249
页数：2
相关论文
共 50 条
  • [41] Relationship between CYP2C8 and CYP2C9 genotypes and diclofenac metabolism in Spanish healthy volunteers.
    Dorado, P.
    Cavaco, I
    Caceres, M. C.
    Píedade, R.
    Ribeiro, V
    LLerena, A.
    ACTA PHARMACOLOGICA SINICA, 2006, 27 : 229 - 229
  • [42] Genetic polymorphisms of CYP2C8 and CYP2C9 influence diurnal blood pressure parameters in elderly subjects
    Gunes, A.
    Karakucuk, E. H.
    Scordo, M. G.
    Zengil, H.
    Dahl, M. -L.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2007, 37 : 48 - 48
  • [43] Evaluation of the Relationship between Sex, Polymorphisms in CYP2C8 and CYP2C9, and Pharmacokinetics of Angiotensin Receptor Blockers
    Cabaleiro, Teresa
    Roman, Manuel
    Ochoa, Dolores
    Talegon, Maria
    Prieto-Perez, Rocio
    Wojnicz, Aneta
    Lopez-Rodriguez, Rosario
    Novalbos, Jesus
    Abad-Santos, Francisco
    DRUG METABOLISM AND DISPOSITION, 2013, 41 (01) : 224 - 229
  • [44] Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9
    Calvo, Adriana Maria
    Zupelari-Goncalves, Paulo
    Dionisio, Thiago Jose
    Brozoski, Daniel Thomas
    Faria, Flavio Augusto
    Santos, Carlos Ferreira
    JOURNAL OF PAIN RESEARCH, 2017, 10 : 1581 - 1589
  • [45] Safety of voriconazole in a patient with CYP2C9*2/CYP2C9*2 genotype
    Geist, Marcus J. P.
    Egerer, Gerlinde
    Burhenne, Juergen
    Mikus, Gerd
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (09) : 3227 - 3228
  • [46] Mild hypoglycaemic attacks induced by sulphonylureas related to CYP2C9, CYP2C19 and CYP2C8 polymorphisms in routine clinical setting
    Gokalp, Osman
    Gunes, Arzu
    Cam, Hakan
    Cure, Erkan
    Aydin, Osman
    Tamer, Mehmet Numan
    Scordo, Maria Gabriella
    Dahl, Marja-Liisa
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 67 (12) : 1223 - 1229
  • [47] Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts
    Pan, Yan
    Tiong, Kai Hung
    Abd-Rashid, Badrul Amini
    Ismail, Zakiah
    Ismail, Rushli
    Mak, Joon Wah
    Ong, Chin Eng
    JOURNAL OF ETHNOPHARMACOLOGY, 2012, 143 (02) : 586 - 591
  • [48] Mild hypoglycaemic attacks induced by sulphonylureas related to CYP2C9, CYP2C19 and CYP2C8 polymorphisms in routine clinical setting
    Osman Gökalp
    Arzu Gunes
    Hakan Çam
    Erkan Cure
    Osman Aydın
    Mehmet Numan Tamer
    Maria Gabriella Scordo
    Marja-Liisa Dahl
    European Journal of Clinical Pharmacology, 2011, 67 : 1223 - 1229
  • [49] Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP
    Tan, Ming-Liang
    Yoshida, Kenta
    Zhao, Ping
    Zhang, Lei
    Nolin, Thomas D.
    Piquette-Miller, Micheline
    Galetin, Aleksandra
    Huang, Shiew-Mei
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 103 (05) : 854 - 867
  • [50] Distribution of CYP2C9*13 allele in the Chinese Han and the long-range haplotype containing CYP2C9*13 and CYP2C19*2
    Si, Dayong
    Wang, Juan
    Zhang, Yifan
    Zhong, Dafang
    Zhou, Hui
    BIOPHARMACEUTICS & DRUG DISPOSITION, 2012, 33 (06) : 342 - 345
12345