High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions

被引：0
|
作者：
Roberto Di Niro
Luka Mesin
Nai-Ying Zheng
Jorunn Stamnaes
Michael Morrissey
Jane-Hwei Lee
Min Huang
Rasmus Iversen
M Fleur du Pré
Shuo-Wang Qiao
Knut E A Lundin
Patrick C Wilson
Ludvig M Sollid
机构：
[1] University of Oslo and Oslo University Hospital-Rikshospitalet,Centre for Immune Regulation and Department of Immunology
[2] The Gwenn Knapp Center for Lupus and Immunology Research,Department of Medicine
[3] The University of Chicago,Department of Medicine
[4] Oslo University Hospital-Rikshospitalet,undefined
[5] University of Oslo,undefined
[6] Section of Rheumatology,undefined
[7] The University of Chicago,undefined
[8] The Committee on Immunology,undefined
[9] The University of Chicago,undefined
来源：
Nature Medicine | 2012年 / 18卷
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摘要：
IgA antibodies directed against tissue transglutaminase 2 (TG2) are used as a serological marker of celiac disease. Ludvig M. Sollid and his colleagues provide an unbiased and thorough characterization of the mucosal antibody response directly from the effector compartment. They report that TG2-specific plasma cells are expanded in the duodenal mucosa of individuals with celiac disease. Antibodies cloned from these cells are of high affinity, show a restricted repertoire and minimal somatic hypermutation, and do not inhibit TG2 enzymatic activity.
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页码：441 / 445
页数：4
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