Antimicrobial, Antifungal and Enzymatic Profiling of Newly Synthesized Heavy Metal Complexes of Gemifloxacin

Three new heavy metal complexes of gemifloxacin (GMFX) were synthesized in 2:1 (L:M) ratio having good percent yield, characterized through physico-chemical and spectroscopic parameters including UV-Vis, TLC, FT-IR, NMR, and elemental (CHN) analysis. The gemifloxacin binds with metals (As, Ag, and Pb) bi-dentately as evident from the spectroscopic studies. These newly synthesized heavy metal complexes of gemifloxacin have been evaluated for their biological activities (antimicrobial and antifungal activities). Their enzymatic profiling was also determined against urease and alpha-chymotrypsin. Results obtained were then statistically analyzed through one way ANOVA and Dunnett’s test by using SPSS version 20.0 revealing that gemifloxacin act as bidentate ligand in complexation with heavy metals, and all newly synthesized complexes possess good antibacterial activities against P.mirabilis, S. typhi, E. coli, P. aureogenosa, K. pneumonia and S. flexneri. Complexes G-M13 and G-M11 showed increased activity against Citrobacter species, while G-M12 showed increased activity against C. albicans in comparison to gemifloxacin. Against S. faetures and S. aureus, G-M13 and G-M12 showed increased activity while G-M11 showed less activity than gemifloxacin. These complexes also possess mild to moderate activity against urease, whereas synthesized complexes show reduced response against α-chymotrypsin. Further emphasis and research on these complexes may place these as urease specific inhibitors in therapeutic agents’ index.