Mitochondrial DNA stress primes the antiviral innate immune response

被引：0
|
作者：
A. Phillip West
William Khoury-Hanold
Matthew Staron
Michal C. Tal
Cristiana M. Pineda
Sabine M. Lang
Megan Bestwick
Brett A. Duguay
Nuno Raimundo
Donna A. MacDuff
Susan M. Kaech
James R. Smiley
Robert E. Means
Akiko Iwasaki
Gerald S. Shadel
机构：
[1] Yale School of Medicine,Department of Pathology
[2] Yale School of Medicine,Department of Immunobiology
[3] Li Ka Shing Institute of Virology,Department of Medical Microbiology and Immunology
[4] University of Alberta,Department of Pathology and Immunology
[5] Edmonton,Department of Genetics
[6] Alberta T6G 2S2,undefined
[7] Canada,undefined
[8] Washington University School of Medicine,undefined
[9] Howard Hughes Medical Institute,undefined
[10] Yale School of Medicine,undefined
[11] Present addresses: Institute for Stem Cell Biology and Regenerative Medicine,undefined
[12] Stanford University School of Medicine,undefined
[13] Stanford,undefined
[14] California 94305,undefined
[15] USA (M.C.T.); Department of Chemistry,undefined
[16] Linfield College,undefined
[17] McMinnville,undefined
[18] Oregon 97128,undefined
[19] USA (M.B.); Institute for Cellular Biochemistry,undefined
[20] Universitätsmedizin Göttingen,undefined
[21] 37073 Göttingen,undefined
[22] Germany (N.R.).,undefined
来源：
Nature | 2015年 / 520卷
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摘要：
Mitochondrial DNA stress potentiates type I interferon responses via activation of the cGAS–STING–IRF3 pathway.
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收藏
页码：553 / 557
页数：4
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