Increased cerebral vascular resistance underlies preserved cerebral blood flow in response to orthostasis in humans on a high-salt diet

被引：0
|
作者：
Dijana Dumančić
Ana Stupin
Maja Kožul
Vatroslav Šerić
Aleksandar Kibel
Nandu Goswami
Bianca Brix
Željko Debeljak
Rudolf Scitovski
Ines Drenjančević
机构：
[1] Josip Juraj Strossmayer University of Osijek,Department of Physiology and Immunology, Faculty of Medicine
[2] University Hospital Centre Osijek,Department of Diagnostic and Interventional Radiology
[3] University Hospital Centre Osijek,Department of Dermatology and Venereology
[4] University Hospital Centre Osijek,Department of Clinical Laboratory Diagnostics
[5] University Hospital Centre Osijek,Department of Heart and Vascular Diseases
[6] Medical University of Graz,Physiology Division, Otto Loewi Research Center
[7] Josip Juraj Strossmayer University of Osijek,Department of Pharmacology, Faculty of Medicine
[8] Josip Juraj Strossmayer University of Osijek,Department of Mathematics
来源：
European Journal of Applied Physiology | 2023年 / 123卷
关键词：
High salt intake; Transcranial Doppler ultrasound; Orthostatic test; Middle cerebral artery; Endothelium-dependent vasodilation; Catecholamine; Blood pressure; Cerebral autoregulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cerebral blood flow autoregulation protects brain tissue from blood pressure variations and maintains cerebral perfusion pressure by changes in vascular resistance. High salt (HS) diet impairs endothelium-dependent vasodilation in many vascular beds, including cerebral microcirculation, and may affect vascular resistance. The aim of present study was to determine if 7-day HS diet affected the reactivity of middle cerebral artery (MCA) to orthostatic challenge in healthy human individuals, and if autoregulatory mechanisms and sympathetic neural regulation were involved in this phenomenon.
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页码：923 / 933
页数：10
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