Vaccination of patients with autoimmune inflammatory rheumatic diseases

As patients with an autoimmune inflammatory rheumatic disease (AIRD) are at increased risk of infection, vaccination could be of paramount importanceVaccination of patients with an AIRD is complicated by possible decreased efficacy of the vaccine and the risk of exacerbating underlying diseaseMost vaccinations of patients with an AIRD seem to be effective; however, efficacy is dependent on the vaccine used, the type of AIRD and the medication regimenAlthough some vaccines have been reported to induce autoimmune disorders, disease activity was not increased after vaccination in studies evaluating vaccination of patients with an AIRDMore research on vaccination of patients with an AIRD is needed, in particular regarding infections, adverse effects of vaccination and the influence of immunomodulatory therapies on vaccination efficacy