Recent progress in broadly neutralizing antibodies to HIV

被引：0
|
作者：
Devin Sok
Dennis R. Burton
机构：
[1] The Scripps Research Institute,Department of Immunology and Microbiology
[2] IAVI Neutralizing Antibody Center,undefined
[3] The Scripps Research Institute,undefined
[4] Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery,undefined
[5] The Scripps Research Institute,undefined
[6] International AIDS Vaccine Initiative,undefined
[7] Ragon Institute of MGH,undefined
[8] MIT,undefined
[9] and Harvard,undefined
来源：
Nature Immunology | 2018年 / 19卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this Review, we highlight some recent developments in the discovery and application of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); i.e., antibodies able to neutralize diverse isolates of HIV. We consider the characterization of novel bnAbs, recent data on the effects of bnAbs in vivo in humans and animal models, and the importance of both kinds of data for the application of Abs to prophylaxis and therapy and to guide vaccine design. We seek to place newly discovered bnAbs in the context of existing bnAbs, and we explore the various characteristics of the antibodies that are most desirable for different applications.
引用
收藏
页码：1179 / 1188
页数：9
相关论文
共 50 条
  • [41] Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir
    Chun, Tae-Wook
    Murray, Danielle
    Justement, Jesse S.
    Blazkova, Jana
    Hallahan, Claire W.
    Fankuchen, Olivia
    Gittens, Kathleen
    Benko, Erika
    Kovacs, Colin
    Moir, Susan
    Fauci, Anthony S.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (36) : 13151 - 13156
  • [42] Effective HIV vaccine: narrow path to broadly neutralizing antibodies?
    Wagner, Ralf
    [J]. CURRENT OPINION IN HIV AND AIDS, 2017, 12 (03) : 191 - 194
  • [43] Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
    Sok, D.
    Le, K.
    Vadnais, M.
    Saye-Francisco, K.
    Kong, L.
    Stanfield, R.
    Jardine, J.
    Ruiz, J.
    Ramos, A.
    Liang, C-H
    Chen, P.
    Criscitiello, M.
    Waithaka, M.
    Wilson, I.
    Smider, V.
    Burton, D.
    [J]. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2017, 20 : 4 - 5
  • [44] Designer antigens for elicitation of broadly neutralizing antibodies against HIV
    Kok, Tuckweng
    Gaeguta, Adriana
    Finnie, John
    Gorry, Paul R.
    Churchill, Melissa
    Li, Peng
    [J]. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2014, 3
  • [45] A vaccine strategy for inducing broadly neutralizing antibodies against HIV
    Marchal, Iris
    [J]. NATURE BIOTECHNOLOGY, 2024, 42 (06) : 847 - 847
  • [46] Broadly neutralizing antibodies for HIV-1 prevention and therapy
    Julg, Boris
    Barouch, Dan
    [J]. SEMINARS IN IMMUNOLOGY, 2021, 51
  • [47] HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
    Florian Klein
    Ariel Halper-Stromberg
    Joshua A. Horwitz
    Henning Gruell
    Johannes F. Scheid
    Stylianos Bournazos
    Hugo Mouquet
    Linda A. Spatz
    Ron Diskin
    Alexander Abadir
    Trinity Zang
    Marcus Dorner
    Eva Billerbeck
    Rachael N. Labitt
    Christian Gaebler
    Paola M. Marcovecchio
    Reha-Baris Incesu
    Thomas R. Eisenreich
    Paul D. Bieniasz
    Michael S. Seaman
    Pamela J. Bjorkman
    Jeffrey V. Ravetch
    Alexander Ploss
    Michel C. Nussenzweig
    [J]. Nature, 2012, 492 : 118 - 122
  • [48] Advancing HIV Broadly Neutralizing Antibodies: From Discovery to the Clinic
    Spencer, David A.
    Shapiro, Mariya B.
    Haigwood, Nancy L.
    Hessell, Ann J.
    [J]. FRONTIERS IN PUBLIC HEALTH, 2021, 9
  • [49] Pharmacokinetics and Immunogenicity of Broadly Neutralizing HIV Monoclonal Antibodies in Macaques
    Rosenberg, Yvonne
    Sack, Markus
    Montefiori, David
    Labranche, Celia
    Lewis, Mark
    Urban, Lori
    Mao, Lingjun
    Fischer, Rainer
    Jiang, Xiaoming
    [J]. PLOS ONE, 2015, 10 (03):
  • [50] Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
    Devin Sok
    Khoa M. Le
    Melissa Vadnais
    Karen L. Saye-Francisco
    Joseph G. Jardine
    Jonathan L. Torres
    Zachary T. Berndsen
    Leopold Kong
    Robyn Stanfield
    Jennifer Ruiz
    Alejandra Ramos
    Chi-Hui Liang
    Patricia L. Chen
    Michael F. Criscitiello
    Waithaka Mwangi
    Ian A. Wilson
    Andrew B. Ward
    Vaughn V. Smider
    Dennis R. Burton
    [J]. Nature, 2017, 548 : 108 - 111
12345