Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)

被引：0

作者：

Holz, Anja ^{[1
,2
]}

Obi, Nadia ^{[1
,3
]}

Ahrens, Wolfgang ^{[4
,5
]}

Berger, Klaus ^{[6
]}

Bohn, Barbara ^{[7
]}

Brenner, Hermann ^{[8
]}

Fischer, Beate ^{[9
]}

Fricke, Julia ^{[10
]}

Fuehrer, Amand ^{[11
]}

Gastell, Sylvia ^{[12
]}

Greiser, Karin Halina ^{[13
]}

Harth, Volker ^{[3
]}

Heise, Jana-Kristin ^{[14
]}

Holleczek, Bernd ^{[15
]}

Keil, Thomas ^{[10
,16
,17
]}

Klett-Tammen, Carolina J. ^{[18
]}

Leitzmann, Michael ^{[9
]}

Lieb, Wolfgang ^{[19
]}

Meinke-Franze, Claudia ^{[20
]}

Michels, Karin B. ^{[21
,22
]}

Mikolajczyk, Rafael ^{[11
]}

Nimptsch, Katharina ^{[23
]}

Peters, Annette ^{[24
,25
]}

Pischon, Tobias ^{[23
,26
,27
,28
,29
]}

Riedel, Oliver ^{[4
]}

Schikowski, Tamara ^{[30
]}

Schipf, Sabine ^{[20
]}

Schmidt, Boerge ^{[31
]}

Schulze, Matthias B. ^{[32
,33
]}

Stang, Andreas ^{[31
,34
]}

Hellwig, Kerstin ^{[35
]}

Riemann-Lorenz, Karin ^{[36
]}

Heesen, Christoph ^{[36
,37
]}

Becher, Heiko ^{[38
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf UKE, Inst Med Biometry & Epidemiol IMBE, Martinistr 52, D-20246 Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf UKE, Inst Tumor Biol, Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf UKE, Inst Occupat & Maritime Med ZfAM, Hamburg, Germany

[4] Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany

[5] Univ Bremen, Bremen, Germany

[6] Univ Munster, Inst Epidemiol & Social Med, Munster, Germany

[7] NAKO EV, Heidelberg, Germany

[8] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Div Prevent Oncol, Heidelberg, Germany

[9] Univ Regensburg, Inst Epidemiol & Prevent Med, Regensburg, Germany

[10] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany

[11] Martin Luther Univ Halle Wittenberg, Med Sch, Interdisciplinary Ctr Hlth Sci, Inst Med Epidemiol Biometr & Informat IMEBI, Halle, Saale, Germany

[12] German Inst Human Nutr Potsdam Rehbrucke, NAKO Study Ctr, Nuthetal, Germany

[13] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[14] Helmholtz Ctr Infect Res HZI, Hannover, Germany

[15] Saarland Canc Registry, Saarbrucken, Germany

[16] Univ Wurzburg, Inst Clin Epidemiol & Biometry, Wurzburg, Germany

[17] Bavarian Hlth & Food Safety Author, State Inst Hlth 1, Erlangen, Germany

[18] Helmholtz Ctr Infect Res HZI, Dept Epidemiol, Braunschweig, Germany

[19] Univ Kiel, Inst Epidemiol, Kiel, Germany

[20] Univ Med Greifswald, Inst Community Med, Greifswald, Germany

[21] Univ Freiburg, Inst Prevent & Canc Epidemiol, Fac Med, Freiburg, Germany

[22] Univ Freiburg, Med Ctr, Freiburg, Germany

[23] Max Delbruck Ctr Mol Med Helmholtz Assoc MDC, Mol Epidemiol Res Grp, Berlin, Germany

[24] Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth GmbH, Neuherberg, Germany

[25] Ludwig Maximilians Univ Munchen, Inst Med Informat Proc Biometry & Epidemiol, Epidemiol, Munich, Germany

[26] Max Delbruck Ctr Mol Med Helmholtz Assoc MDC, Biobank Technol Platform, Berlin, Germany

[27] Charite Univ Med Berlin, Berlin, Germany

[28] Free Univ Berlin, Berlin, Germany

[29] Humboldt Univ, Berlin, Germany

[30] IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany

[31] Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, Med Fac, Essen, Germany

[32] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[33] Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany

[34] Boston Univ, Sch Publ Hlth, Dept Epidemiol, 715 Albany St,Talbot Bldg, Boston, MA 02118 USA

[35] Clin Ruhr Univ Bochum, Neurol Clin, Katholisches Klinikum Bochum, Bochum, Germany

[36] Univ Med Ctr Hamburg Eppendorf UKE, Inst Neuroimmunol & Multiple Sclerosis INIMS, Ctr Mol Neurobiol Hamburg ZMNH, Hamburg, Germany

[37] Univ Med Ctr Hamburg Eppendorf UKE, Dept Neurol, Hamburg, Germany

[38] Univ Hosp Heidelberg, Inst Global Hlth, Heidelberg, Germany

来源：

BMC NEUROLOGY | 2024年 / 24卷 / 01期

关键词：

Multiple Sclerosis; Childhood; Adolescence; Epidemiology; EARLY-LIFE; AGE; 20; RISK; EXPOSURE; BIRTH; PREVENTION; WEIGHT;

D O I：

10.1186/s12883-024-03620-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk.Methods Data from the baseline assessment of the German National Cohort (NAKO) were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between childhood and adolescence factors and risk of MS. Analyses stratified by sex were conducted.Results Among a total of 204,273 participants, 858 reported an MS diagnosis. Male sex was associated with a decreased MS risk (HR 0.48; 95% CI 0.41-0.56), while overweight (HR 2.03; 95% CI 1.41-2.94) and obesity (HR 1.89; 95% CI 1.02-3.48) at 18 years of age compared to normal weight were associated with increased MS risk. Having been breastfed for <= 4 months was associated with a decreased MS risk in men (HR 0.59; 95% CI 0.40-0.86) compared to no breastfeeding. No association with MS risk was observed for the remaining factors.Conclusions Apart from overweight and obesity at the age of 18 years, we did not observe considerable associations with MS risk. The proportion of cases that can be explained by childhood and adolescence factors examined in this study was low. Further investigations of the association between the onset of overweight and obesity in childhood and adolescence and its interaction with physical activity and MS risk seem worthwhile.

引用

页数：10

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