Wild-type microglia arrest pathology in a mouse model of Rett syndrome

被引：0
|
作者：
Noël C. Derecki
James C. Cronk
Zhenjie Lu
Eric Xu
Stephen B. G. Abbott
Patrice G. Guyenet
Jonathan Kipnis
机构：
[1] School of Medicine,Department of Neuroscience
[2] University of Virginia,Department of Pharmacology
[3] Graduate Program in Neuroscience,undefined
[4] School of Medicine,undefined
[5] University of Virginia,undefined
[6] Medical Scientist Training Program,undefined
[7] School of Medicine,undefined
[8] University of Virginia,undefined
[9] Undergraduate School of Arts and Sciences,undefined
[10] University of Virginia,undefined
[11] School of Medicine,undefined
[12] University of Virginia,undefined
来源：
Nature | 2012年 / 484卷
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学科分类号：
摘要：
Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.
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页码：105 / 109
页数：4
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