Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

被引：0

作者：

Ronald E Blanton

Luciano K Silva

Vanessa G Morato

Antonio R Parrado

Juarez P Dias

Paulo R S Melo

Eliana A G Reis

Katrina A B Goddard

Márcio R T Nunes

Sueli G Rodrigues

Pedro F C Vasconcelos

Jesuina M Castro

Mitermayer G Reis

Maurício L Barreto

M Glória Teixeira

机构：

[1] Case Western Reserve University,Division of Genetic Epidemiology, Department of Epidemiology & Biostatistics

[2] Center for Global Health and Diseases,Department of Arbovirology and Hemorrhagic Fever

[3] Fundação Oswaldo Cruz,undefined

[4] Centro de Pesquisas Gonçalo Moniz,undefined

[5] Laboratory of Pathology and Molecular Biology,undefined

[6] Rua Waldemar Falcão,undefined

[7] 121,undefined

[8] Universidade Federal da Bahia,undefined

[9] Institute of Collective Health,undefined

[10] Case Western Reserve University,undefined

[11] Wolstein Research Building,undefined

[12] Secretaria da Saúde do Estado da Bahia,undefined

[13] 4a Avenida do CAB,undefined

[14] no 400,undefined

[15] Lado B,undefined

[16] CAB,undefined

[17] Instituto Evandro Chagas,undefined

来源：

European Journal of Human Genetics | 2008年 / 16卷

关键词：

ethnicity; race; population structure; socioeconomic status; DENV3;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.

引用

页码：762 / 765

页数：3

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