Extracellular Matrix in the Regulation of Stem Cell Differentiation

被引：0
|
作者：
E. S. Novoseletskaya
O. A. Grigorieva
A. Yu. Efimenko
N. I. Kalinina
机构：
[1] Lomonosov Moscow State University,Institute for Regenerative Medicine, Medical Research and Education Center
[2] Faculty of Medicine,Lomonosov Moscow State University
来源：
Biochemistry (Moscow) | 2019年 / 84卷
关键词：
extracellular matrix; stem cells; differentiation; stem cell niche; extracellular vesicles; decellularization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Extracellular matrix (ECM) proteins fill the space between cells in multicellular organisms, contributing to the structure of organs and tissues. The mechanical properties of ECM are well studied. At present, the role of individual ECM components and the three-dimensional tissue-specific matrices in the regulation of cell functional activity, proliferation, migration, acquisition of a specialized phenotype and its maintenance is intensively studied. In this review, we described main ECM structural proteins, enzymes, and extracellular vesicles and present the data on the participation of ECM components in the regulation of stem cell differentiation and self-maintenance, as well as approaches to the modeling of stem cells microenvironment using decellularized ECM.
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收藏
页码：232 / 240
页数：8
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