A modern state of the following problems of magmatogene hydrothermal mineralization are considered in this paper: Dependence of ore types from a redox state of ore producing magmas; D.S. Korzhinskii’s principle of acid-base interaction as a possible variety of Le Chatelier’s principle; the structural features of zonal near-ore alkaline and acidic metasomatites and related revised formula of the mineralogical phase rule; dependence of acidity-alkalinity of fluids from NaCl and KCl hydrolysis at different P-T environments, as well as from subcritical fluid’s heterogenization; the features and reason of general evolution of mineralization within a single metallogenic cycle; mineralization from heterophase fluids at the postorogenic deposits of W, Sn, Au, Ag, Cu, Pb, Zn, and Hg related to acidic metasomatites; evidence and reason of intermittent (multi-stage) mineralization on the background of general evolution of composition and properties of fluids; as well as (8) some guidelines for local ore prediction based on above analysis.