New Pyridopyrimidone Derivatives: Synthesis, Molecular Docking Studies, and Potential Anticancer Activity

被引：0
|
作者：
N. M. Khalifa
H. M. Alkahtani
M. A. Al-Omar
A. H. Bakheit
机构：
[1] King Saud University,Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy
[2] National Research Centre,Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Division
[3] King Saud University,Pharmaceutical Chemistry Department, College of Pharmacy
[4] Al-Neelain University,Chemistry Department, Faculty of Science and Technology
来源：
Russian Journal of General Chemistry | 2019年 / 89卷
关键词：
pyridopyrimidones; cytotoxic agents; molecular docking;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new series of pyrido[2,3-d]pyrimidones incorporated pyrazoles and fused triazoles are synthesized and tested in vitro for cytotoxic effect against cancer cell lines: HePG-2, HCT-116, MCF-7, PC-3, and A-549. Their inhibition of protein kinase is assessed. The highest growth inhibitory (IC50 0.3 µM) effect is determined for one of compounds as compared with doxorubicin (IC50 0.6 µM). A modeling study is performed for approaching the compounds mode of binding and their similarity with the positive control drugs.
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页码：1683 / 1690
页数：7
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