New Pyridopyrimidone Derivatives: Synthesis, Molecular Docking Studies, and Potential Anticancer Activity

被引：1
|
作者：
Khalifa, N. M. [1 ,2 ]
Alkahtani, H. M. [3 ]
Al-Omar, M. A. [1 ,3 ]
Bakheit, A. H. [3 ,4 ]
机构：
[1] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, DEDC, Riyadh 11451, Saudi Arabia
[2] Natl Res Ctr, Therapeut Chem Dept, Pharmaceut & Drug Ind Div, Cairo 12622, Egypt
[3] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, Riyadh 11451, Saudi Arabia
[4] Al Neelain Univ, Fac Sci & Technol, Chem Dept, Khartoum, Sudan
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 08期
关键词：
pyridopyrimidones; cytotoxic agents; molecular docking; ANTITUMOR-ACTIVITY; GROWTH;
D O I：
10.1134/S107036321908022X
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new series of pyrido[2,3-d]pyrimidones incorporated pyrazoles and fused triazoles are synthesized and tested in vitro for cytotoxic effect against cancer cell lines: HePG-2, HCT-116, MCF-7, PC-3, and A-549. Their inhibition of protein kinase is assessed. The highest growth inhibitory (IC50 0.3 mu M) effect is determined for one of compounds as compared with doxorubicin (IC50 0.6 mu M). A modeling study is performed for approaching the compounds mode of binding and their similarity with the positive control drugs.
引用
收藏
页码：1683 / 1690
页数：8
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