Addicting diverse bacteria to a noncanonical amino acid

被引：0
|
作者：
Tack D.S. [1 ]
Ellefson J.W. [1 ]
Thyer R. [1 ]
Wang B. [1 ]
Gollihar J. [1 ]
Forster M.T. [1 ]
Ellington A.D. [1 ]
机构：
[1] Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX
来源：
Nature Chemical Biology | 2016年 / 12卷 / 3期
关键词：
D O I：
10.1038/nchembio.2002
中图分类号：
学科分类号：
摘要：
Engineered orthogonal translation systems have greatly enabled the expansion of the genetic code using noncanonical amino acids (NCAAs). However, the impact of NCAAs on organismal evolution remains unclear, in part because it is difficult to force the adoption of new genetic codes in organisms. By reengineering TEM-1 β-lactamase to be dependent on a NCAA, we maintained bacterial NCAA dependence for hundreds of generations without escape. © 2016 Nature America, Inc. All rights reserved.
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页码：138 / 140
页数：2
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