Apoptosis, Heart Failure, Ischemic Heart Disease

被引：0
|
作者：
Nilanjana Maulik
Dipak K. Das
机构：
[1] University of Connecticut Medical Center,Cardiovascular Division, Department of Surgery
来源：
Heart Failure Reviews | 1999年 / 4卷 / 2期
关键词：
apoptosis; heart failure; ischemia/reperfusion; free radicals; antioxidants; phospholipids;
D O I：
10.1023/A:1009876508989
中图分类号：
学科分类号：
摘要：
Cardiomyocytes die by apoptosis in addition to necrosis under a variety of pathological conditions including heart failure, cardiomyopathy, and ischemia/reperfusion. This review summarizes current status of the literature demonstrating evidence of apoptotic cell death in heart failure and ischemic heart disease. Apoptotic cells have been detected in failing hearts of human and dog. Ischemia up to 2 hr does not induce apoptosis, but reperefusion of ischemic heart can trigger apoptosis and DNA fragmentation. Apoptosis appears to occur in a varity of animal species including mouse, rat, rabbit, swine, dog and human suggesting that this is not species-specific.
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页码：1 / 9
页数：8
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