Anticancer activity of new depsipeptide compound isolated from an endophytic fungus

被引：0
|
作者：
Shilpa Amit Verekar
Prabhu Dutt Mishra
Eyyammadichiyil Sankaranarayanan Sreekumar
Sunil Kumar Deshmukh
Heinz-Herbert Fiebig
Gerhard Kelter
Armin Maier
机构：
[1] Piramal Enterprises Limited,
[2] Oncotest GmbH,undefined
[3] Institut für experimentelle Onkologie,undefined
来源：
The Journal of Antibiotics | 2014年 / 67卷
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摘要：
A novel depsipeptide (PM181110) was purified from an endophytic fungus Phomopsis glabrae isolated from the leaves of Pongamia pinnata (family Fabaceae). The chemical structure of PM181110 was elucidated using physiochemical properties, 2D NMR and other spectroscopic methods. PM181110 is very close in structure to FE399. The compound exhibited in vitro anticancer activity against 40 human cancer cell lines with a mean IC50 value of 0.089 μM and ex vivo efficacy towards 24 human tumor xenografts (mean IC50=0.245 μM).
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页码：697 / 701
页数：4
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