Total Synthesis of Lignan Lactone (–)-Hinokinin

被引：8
|
作者：
Zhou Q.-L. [1 ]
Wang H.-J. [1 ]
Tang P. [1 ]
Song H. [2 ]
Qin Y. [2 ]
机构：
[1] Innovative Drug Research Centre, Chongqing University, Chongqing
[2] Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu
来源：
Natural Products and Bioprospecting | 2015年 / 5卷 / 5期
关键词：
Cascade reaction; Hinokinin; Lignan; Total synthesis;
D O I：
10.1007/s13659-015-0073-3
中图分类号：
学科分类号：
摘要：
This research paper is aimed at studying the total synthesis of pharmacologically active lignan (–)-hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal butyrolactonimidate intermediate. © 2015, The Author(s).
引用
收藏
页码：255 / 261
页数：6
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