In this paper, we propose a compact difference scheme of second order temporal convergence for the analysis of sub-diffusion fourth-order neutral fractional delay differential equations. In this regard, a difference scheme combining the compact difference operator for spatial discretization along with L2-1σ\documentclass[12pt]{minimal}
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\begin{document}$$L2-1_{\sigma }$$\end{document} formula for Caputo fractional derivative is constructed and analyzed. Unique solvability, stability, and convergence of the proposed scheme are proved using the discrete energy method in L2\documentclass[12pt]{minimal}
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\begin{document}$$L_2$$\end{document} norm. Established scheme is of second-order convergence in time and fourth-order convergence in spatial dimension, i.e., O(τ3-α+h4)\documentclass[12pt]{minimal}
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\begin{document}$$O(\tau ^{3-\alpha }+h^4)$$\end{document}, where τ\documentclass[12pt]{minimal}
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\begin{document}$$\tau$$\end{document} and h are time and space mesh sizes respectively and α∈(0,1)\documentclass[12pt]{minimal}
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\begin{document}$$\alpha \in (0,1)$$\end{document}. Finally, some numerical experiments are given to show the authenticity, efficiency, and accuracy of our theoretical results.