Mimicking breast cancer-induced bone metastasis in vivo: current transplantation models and advanced humanized strategies

被引:0
|
作者
Laure Thibaudeau
Verena M. Quent
Boris M. Holzapfel
Anna V. Taubenberger
Melanie Straub
Dietmar W. Hutmacher
机构
[1] Queensland University of Technology,Regenerative Medicine Group, Institute of Health and Biomedical Innovation
[2] University Hospital Erlangen,Department of Obstetrics and Gynecology
[3] Friedrich-Alexander University Erlangen-Nuremberg,Orthopedic Center for Musculoskeletal Research
[4] University of Wuerzburg,George W Woodruff School of Mechanical Engineering
[5] Biotec TU Dresden,undefined
[6] Institute of Pathology,undefined
[7] Technical University Munich,undefined
[8] Georgia Institute of Technology,undefined
[9] Institute for Advanced Study,undefined
[10] Technical University Munich,undefined
来源
Cancer and Metastasis Reviews | 2014年 / 33卷
关键词
Bone metastasis; Breast cancer; Osteotropism; Humanized xenograft model; Tissue engineering;
D O I
暂无
中图分类号
学科分类号
摘要
Bone metastasis is a complication that occurs in 80 % of women with advanced breast cancer. Despite the prevalence of bone metastatic disease, the avenues for its clinical management are still restricted to palliative treatment options. In fact, the underlying mechanisms of breast cancer osteotropism have not yet been fully elucidated due to a lack of suitable in vivo models that are able to recapitulate the human disease. In this work, we review the current transplantation-based models to investigate breast cancer-induced bone metastasis and delineate the strengths and limitations of the use of different grafting techniques, tissue sources, and hosts. We further show that humanized xenograft models incorporating human cells or tissue grafts at the primary tumor site or the metastatic site mimic more closely the human disease. Tissue-engineered constructs are emerging as a reproducible alternative to recapitulate functional humanized tissues in these murine models. The development of advanced humanized animal models may provide better platforms to investigate the mutual interactions between human cancer cells and their microenvironment and ultimately improve the translation of preclinical drug trials to the clinic.
引用
收藏
页码:721 / 735
页数:14
相关论文
共 50 条
  • [21] Mouse models of breast cancer metastasis to bone
    Kelsi L. Kretschmann
    Alana L. Welm
    Cancer and Metastasis Reviews, 2012, 31 : 579 - 583
  • [22] Epiberberine inhibits bone metastatic breast cancer-induced osteolysis
    Wei, Chengming
    Shi, Meina
    Wang, Zi
    Lan, Wenjian
    Feng, Na
    Zhang, Fuming
    Liu, Jiachen
    Lang, Jing-Yu
    Lin, Wanjun
    Ma, Wenzhe
    JOURNAL OF ETHNOPHARMACOLOGY, 2024, 327
  • [23] Effects of PGE2 receptor EP4 antagonist on breast cancer-induced bone metastasis and bone destruction in the metastasis region.
    Watanabe, Kenta
    Matsumoto, Chiho
    Hirata, Michiko
    Maruyama, Takayuki
    Inada, Masaki
    Miyaura, Chisato
    JOURNAL OF BONE AND MINERAL RESEARCH, 2014, 29 : S232 - S232
  • [24] Prevention of breast cancer-induced osteolytic bone resorption by benzyl isothiocyanate
    Pore, Subrata K.
    Hahm, Eun-Ryeong
    Latoche, Joseph D.
    Anderson, Carolyn J.
    Shuai, Yongli
    Singh, Shivendra V.
    CARCINOGENESIS, 2018, 39 (02) : 134 - 145
  • [25] Breast cancer bone metastasis and current small therapeutics
    Cicek, Muzaffer
    Oursler, Merry Jo
    CANCER AND METASTASIS REVIEWS, 2006, 25 (04) : 635 - 644
  • [26] VERTEBRAL OSTEOMYELITIS MIMICKING BONE METASTASIS IN BREAST-CANCER PATIENTS
    VORAVUD, N
    THERIAULT, R
    HORTOBAGYI, G
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1992, 15 (05): : 428 - 432
  • [27] Breast cancer bone metastasis and current small therapeutics
    Muzaffer Cicek
    Merry Jo Oursler
    Cancer and Metastasis Reviews, 2006, 25 : 635 - 644
  • [28] Sulforaphane is a novel inhibitor of breast cancer-induced osteolytic bone resorption
    Pore, Subrata K.
    Latoche, Joseph D.
    Anderson, Carolyn J.
    Adamik, Juraj
    Galson, Deborah L.
    Weiss, Kurt R.
    Lee, Boeun
    Watters, Rebecca J.
    Kumta, Prashant N.
    Singh, Shivendra V.
    CANCER RESEARCH, 2019, 79 (13)
  • [29] Regulation of Breast Cancer-induced Bone Lesions by β-Catenin Protein Signaling
    Chen, Yan
    Shi, Heidi Y.
    Stock, Stuart R.
    Stern, Paula H.
    Zhang, Ming
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (49) : 42575 - 42584
  • [30] Proanthocyanidins attenuate breast cancer-induced bone metastasis by inhibiting Irf-3/c-jun activation
    Guo, Shuangfei
    Zhu, Wei
    Yin, Ziqing
    Xiao, Ding
    Zhang, Qiang
    Liu, Tang
    Ni, Jiangdong
    Ouyang, Zhengxiao
    Xie, Hongming
    ANTI-CANCER DRUGS, 2019, 30 (10) : 998 - 1005