Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus

被引：278

作者：

Hong Y.-K. ^{[1
]}

Foreman K. ^{[2
]}

Shin J.W. ^{[1
]}

Hirakawa S. ^{[1
]}

Curry C.L. ^{[2
]}

Sage D.R. ^{[3
]}

Libermann T. ^{[4
]}

Dezube B.J. ^{[3
]}

Fingeroth J.D. ^{[3
]}

Detmar M. ^{[1
]}

机构：

[1] Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129

[2] Loyola University Medical Center, Maywood

[3] Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston

[4] BIDMC Genomics Center, Department of Medicine, Harvard Medical School, Boston

来源：

Nature Genetics | 2004年 / 36卷 / 7期

关键词：

D O I：

10.1038/ng1383

中图分类号：

学科分类号：

摘要：

Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of ∼70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.

引用

页码：683 / 685

页数：2

共 50 条

[41] Pathogenesis and Associated Diseases of Kaposi's Sarcoma-associated Herpesvirus
Lin-ding WANG(State Key Laboratory of Virology
Virologica Sinica, 2007, (03) : 248 - 255
[42] The ubiquitin system and Kaposi's sarcoma-associated herpesvirus
Ashizawa, Akira
Higashi, Chizuka
Masuda, Kazuki
Ohga, Rie
Taira, Takahiro
Fujimuro, Masahiro
FRONTIERS IN MICROBIOLOGY, 2012, 3
[43] Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus
Verma, SC
Robertson, ES
FEMS MICROBIOLOGY LETTERS, 2003, 222 (02) : 155 - 163
[44] Epidemiology and Transmission of Kaposi's Sarcoma-Associated Herpesvirus
Minhas, Veenu
Wood, Charles
VIRUSES-BASEL, 2014, 6 (11): : 4178 - 4194
[45] Kaposi's sarcoma-associated herpesvirus and innate immunity
West, John A.
Damania, Blossom
FUTURE VIROLOGY, 2010, 5 (02) : 185 - 196
[46] An Update of the Virion Proteome of Kaposi Sarcoma-Associated Herpesvirus
Nabiee, Ramina
Syed, Basir
Castano, Jesus Ramirez
Lalani, Rukhsana
Totonchy, Jennifer E.
VIRUSES-BASEL, 2020, 12 (12):
[47] For the future studies of Kaposi's sarcoma-associated herpesvirus
Ueda, Keiji
FRONTIERS IN MICROBIOLOGY, 2012, 3
[48] Insight into the Epigenetics of Kaposi's Sarcoma-Associated Herpesvirus
Srivastava, Anusha
Srivastava, Ankit
Singh, Rajnish Kumar
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (19)
[49] The Chromatin Landscape of Kaposi's Sarcoma-Associated Herpesvirus
Toth, Zsolt
Brulois, Kevin
Jung, Jae U.
VIRUSES-BASEL, 2013, 5 (05): : 1346 - 1373
[50] Pathology of Kaposi's sarcoma-associated herpesvirus infection
Fukumoto, Hitomi
Kanno, Takayuki
Hasegawa, Hideki
Katano, Harutaka
FRONTIERS IN MICROBIOLOGY, 2011, 2

← 1 2 3 4 5 →