Synthesis of pyrazole- and thiazole-annulated 3-R-1,5-dinitro-3-azabicyclo[3.3.1]nonanes

被引：0

作者：

A. V. Puchnin

M. A. Bastrakov

A. M. Starosotnikov

S. V. Popkov

S. A. Shevelev

机构：

[1] D. I. Mendeleev University of Chemical Technology of Russia,N. D. Zelinsky Institute of Organic Chemistry

[2] Russian Academy of Sciences,undefined

来源：

Russian Chemical Bulletin | 2012年 / 61卷

关键词：

azabicyclo[3.3.1]nonanes; reduction; Mannich reaction; nitro group; azoles;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The previously unknown 3-R-1,5-dinitro-3-azabicyclo[3.3.1]nonanes fused to the pyrazole or thiazole rings were synthesized by the reductive cyclization of m-dinitroindazoles and benzothiazoles. The method is based on the reduction of carbon-carbon bonds in the benzene ring, which are activated by the meta-nitro groups, with NaBH4 followed by the Mannich reaction with formaldehyde and primary amines.

引用

页码：596 / 599

页数：3

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