The multifaceted biology of plasmacytoid dendritic cells

被引：0
|
作者：
Melissa Swiecki
Marco Colonna
机构：
[1] Washington University School of Medicine,Department of Pathology and Immunology
[2] Janssen Research & Development,undefined
[3] LLC,undefined
来源：
Nature Reviews Immunology | 2015年 / 15卷
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摘要：
This Review provides an introduction to human and mouse plasmacytoid dendritic cells (pDCs) and their importance in the immune system.We discuss the phenotypes of human and mouse pDCs and the mechanisms that control their development.We explain how pDCs sense nucleic acids and microbial products, as well as their potential role in viral infections and diseases characterized by a type I interferon (IFN) signature, such as systemic lupus erythematosus, psoriasis and type 1 diabetes.We discuss the emerging field of microbiome research and how pDCs can shape mucosal immune responses.We describe how pDCs can be tolerogenic or immunogenic in the context of cancer.Finally, we end by raising several questions regarding the validity of targeting pDCs or their type I IFN production as a therapeutic strategy.
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页码：471 / 485
页数：14
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