T-loops and the origin of telomeres

被引：0
|
作者：
Titia de Lange
机构：
[1] the Laboratory for Cell Biology and Genetics,
[2] Box 159,undefined
[3] The Rockefeller University,undefined
来源：
Nature Reviews Molecular Cell Biology | 2004年 / 5卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Most eukaryotes stabilize the ends of their linear chromosomes with a telomerase-based system. Telomerase maintains specific repetitive sequences, which protect chromosome ends with the help of telomere-binding proteins. How did this elaborate system evolve? Here, I propose that telomere function was originally mediated by t-loops, which could have been generated by prokaryotic DNA-replication factors. These early telomeres would have required only the presence of a few repeats at chromosome ends. Telomerase could have been a later innovation with specific advantages for telomere function and regulation.
引用
收藏
页码：323 / 329
页数：6
相关论文
共 50 条
  • [21] The hyperthermophilic partners Nanoarchaeum and Ignicoccus stabilize their tRNA T-loops via different but structurally equivalent modifications
    Rose, Simon
    Auxilien, Sylvie
    Havelund, Jesper F.
    Kirpekar, Finn
    Huber, Harald
    Grosjean, Henri
    Douthwaite, Stephen
    NUCLEIC ACIDS RESEARCH, 2020, 48 (12) : 6906 - 6918
  • [22] Effect of activation and preactivation on the mechanical behavior and neutral position of stainless steel and beta-titanium T-loops
    de Castro, Saul Matos
    Moreira, Rui
    Braga, Ana Cristina
    Ferreira, Afonso Pinhao
    Pollmann, Maria Cristina
    KOREAN JOURNAL OF ORTHODONTICS, 2015, 45 (04) : 198 - 208
  • [23] Temperature Effects on the Forces, Moments and Moment to Force Ratio of Nickel-Titanium and TMA Symmetrical T-loops
    Lim, Yeen
    Quick, Andrew
    Swain, Michael
    Herbison, Peter
    ANGLE ORTHODONTIST, 2008, 78 (06) : 1035 - 1042
  • [24] Moment-to-force characteristics of preactivated nickel-titanium and titanium-molybdenum alloy symmetrical T-loops
    Rose, Darnell
    Quick, Andrew
    Swain, Michael
    Herbison, Peter
    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 2009, 135 (06) : 757 - 763
  • [25] Finite element analysis of archwire parameters and activation forces on the M/F ratio of vertical, L- and T-loops
    Cai, Yongqing
    BMC ORAL HEALTH, 2020, 20 (01)
  • [26] Pathogenesis-related mutations in the T-loops of human mitochondrial tRNAs affect 3′ end processing and tRNA structure
    Levinger, Louis
    Serjanov, Dmitri
    RNA BIOLOGY, 2012, 9 (03) : 283 - 291
  • [27] Finite element analysis of archwire parameters and activation forces on the M/F ratio of vertical, L- and T-loops
    Yongqing Cai
    BMC Oral Health, 20
  • [28] VECTORCARDIOGRAPHIC STUDY OF SPATIAL P, QRS AND T-LOOPS IN DIABETIC-PATIENTS WITHOUT CLINICALLY APPARENT HEART-DISEASE
    ZONERAICH, O
    ZONERAICH, S
    JOURNAL OF ELECTROCARDIOLOGY, 1977, 10 (03) : 207 - 214
  • [29] GInK, a PII-homologue:: Structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition
    Xu, YB
    Cheah, E
    Carr, PD
    van Heeswijk, WC
    Westerhoff, HV
    Vasudevan, SG
    Ollis, DL
    JOURNAL OF MOLECULAR BIOLOGY, 1998, 282 (01) : 149 - 165
  • [30] The origin of postflare loops
    Sheeley, NR
    Warren, HP
    Wang, YM
    ASTROPHYSICAL JOURNAL, 2004, 616 (02): : 1224 - 1231
12345