Oligopeptides of Chorionic Gonadotropin β-Subunit in Induction of T Cell Differentiation into Treg and Th17

被引：0
|
作者：
S. A. Zamorina
S. V. Shirshev
机构：
[1] Ural Division of the Russian Academy of Sciences,Laboratory of Immunoregulation, Institute of Ecology and Genetics of Microorganisms
来源：
Bulletin of Experimental Biology and Medicine | 2015年 / 160卷
关键词：
chorionic gonadotropin; regulatory oligopeptides (LQGV, AQGV, and VLPALP); Th17; Treg;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role of oligopeptides of chorionic gonadotropin β-subunit (LQGV, AQGV, and VLPALP) in induction of differentiation into T-regulatory lymphocytes (Treg) and IL-17-producing lymphocytes (Th17) was studied in an in vitro system. Chorionic gonadotropin and oligopeptides promoted CD4+ cell differentiation into functionally active Treg (FOXP3+GITR+ and FOXP3+CTLA-4+), while chorionic gonadotropin and AQGV additionally stimulated IL-10 production by these cells. In parallel, chorionic gonadotropin and oligopeptides prevented CD4+ cell differentiation into Th17 lymphocytes (ROR-gt+IL-17A+) and suppressed IL-17A secretion. Hence, oligopeptides of chorionic gonadotropin β-subunit promoted differentiation of CD4+ cells into Treg and, in parallel, suppress Th17 induction, thus virtually completely reproducing the effects of the hormone, which opens new vista for their use in clinical practice.
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页码：72 / 75
页数：3
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