Taurine entry into perilymph of the guinea pig

被引：0

作者：

E. Angelini

M. Teixeira

J.-M. Aran

E. Ferrary

机构：

[1] Laboratoire d’Audiologie Expérimentale et Clinique,

[2] CJF INSERM 97-04,undefined

[3] Université Bordeaux II,undefined

[4] Bordeaux,undefined

[5] France,undefined

[6] INSERM U 426,undefined

[7] Département de Physiologie,undefined

[8] Faculté Xavier Bichat,undefined

[9] Université Paris 7,undefined

[10] F-75018 Paris,undefined

[11] France,undefined

[12] INSERM U 426,undefined

[13] Département de Physiologie,undefined

[14] Faculté Xavier Bichat,undefined

[15] BP416,undefined

[16] 16 rue Henri Huchard,undefined

[17] F-75870 Paris Cedex 18,undefined

[18] France,undefined

来源：

European Archives of Oto-Rhino-Laryngology | 1998年 / 255卷

关键词：

Key words Amino acid transport; Blood-perilymph barrier; Cochlea;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Taurine is a β-aminosulfonic acid and is a ubiquitous amino acid whose role in the cochlea is not well established. In this study, its entry from blood into perilymph was investigated in the guinea pig as animal model. The penetration rate of [3H]taurine (molecular weight 125) into the perilymph of the scala vestibuli was measured 1 and 2 h after the intravenous infusion of [3H]taurine in nephrectomized animals. Results showed a rate of penetration in perilymph related to plasma at 36 ± 4.7% (n = 5) after 1 h and 43 ± 5.6% (n = 5) after 2 h. Compared to the penetration rate of urea (molecular weight 60) and mannitol (molecular weight 186) reported previously in rats, a passive entry of taurine into perilymph through the blood-perilymph barrier is suggested.

引用

页码：331 / 333

页数：2

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